Mirroring everyday clinical practice in clinical trial design: a new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression

BACKGROUND: Randomized, double-blind, placebo-controlled trials constitute the gold standard in clinical research when testing the efficacy of new psychopharmacological interventions in the treatment of major depression. However, the blinded use of placebo has been found to influence clinical trial...

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Detalles Bibliográficos
Autores principales: Severus, Emanuel, Seemüller, Florian, Berger, Michael, Dittmann, Sandra, Obermeier, Michael, Pfennig, Andrea, Riedel, Michael, Frangou, Sophia, Möller, Hans-Jürgen, Bauer, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395582/
https://www.ncbi.nlm.nih.gov/pubmed/22747667
http://dx.doi.org/10.1186/1741-7015-10-67

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