Rational Engineering of Enzyme Allosteric Regulation through Sequence Evolution Analysis

Control of enzyme allosteric regulation is required to drive metabolic flux toward desired levels. Although the three-dimensional (3D) structures of many enzyme-ligand complexes are available, it is still difficult to rationally engineer an allosterically regulatable enzyme without decreasing its ca...

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Detalles Bibliográficos
Autores principales: Yang, Jae-Seong, Seo, Sang Woo, Jang, Sungho, Jung, Gyoo Yeol, Kim, Sanguk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395594/
https://www.ncbi.nlm.nih.gov/pubmed/22807670
http://dx.doi.org/10.1371/journal.pcbi.1002612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395594/
https://www.ncbi.nlm.nih.gov/pubmed/22807670
http://dx.doi.org/10.1371/journal.pcbi.1002612

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