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Three Dopamine Pathways Induce Aversive Odor Memories with Different Stability

Animals acquire predictive values of sensory stimuli through reinforcement. In the brain of Drosophila melanogaster, activation of two types of dopamine neurons in the PAM and PPL1 clusters has been shown to induce aversive odor memory. Here, we identified the third cell type and characterized avers...

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Autores principales: Aso, Yoshinori, Herb, Andrea, Ogueta, Maite, Siwanowicz, Igor, Templier, Thomas, Friedrich, Anja B., Ito, Kei, Scholz, Henrike, Tanimoto, Hiromu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395599/
https://www.ncbi.nlm.nih.gov/pubmed/22807684
http://dx.doi.org/10.1371/journal.pgen.1002768
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author Aso, Yoshinori
Herb, Andrea
Ogueta, Maite
Siwanowicz, Igor
Templier, Thomas
Friedrich, Anja B.
Ito, Kei
Scholz, Henrike
Tanimoto, Hiromu
author_facet Aso, Yoshinori
Herb, Andrea
Ogueta, Maite
Siwanowicz, Igor
Templier, Thomas
Friedrich, Anja B.
Ito, Kei
Scholz, Henrike
Tanimoto, Hiromu
author_sort Aso, Yoshinori
collection PubMed
description Animals acquire predictive values of sensory stimuli through reinforcement. In the brain of Drosophila melanogaster, activation of two types of dopamine neurons in the PAM and PPL1 clusters has been shown to induce aversive odor memory. Here, we identified the third cell type and characterized aversive memories induced by these dopamine neurons. These three dopamine pathways all project to the mushroom body but terminate in the spatially segregated subdomains. To understand the functional difference of these dopamine pathways in electric shock reinforcement, we blocked each one of them during memory acquisition. We found that all three pathways partially contribute to electric shock memory. Notably, the memories mediated by these neurons differed in temporal stability. Furthermore, combinatorial activation of two of these pathways revealed significant interaction of individual memory components rather than their simple summation. These results cast light on a cellular mechanism by which a noxious event induces different dopamine signals to a single brain structure to synthesize an aversive memory.
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spelling pubmed-33955992012-07-17 Three Dopamine Pathways Induce Aversive Odor Memories with Different Stability Aso, Yoshinori Herb, Andrea Ogueta, Maite Siwanowicz, Igor Templier, Thomas Friedrich, Anja B. Ito, Kei Scholz, Henrike Tanimoto, Hiromu PLoS Genet Research Article Animals acquire predictive values of sensory stimuli through reinforcement. In the brain of Drosophila melanogaster, activation of two types of dopamine neurons in the PAM and PPL1 clusters has been shown to induce aversive odor memory. Here, we identified the third cell type and characterized aversive memories induced by these dopamine neurons. These three dopamine pathways all project to the mushroom body but terminate in the spatially segregated subdomains. To understand the functional difference of these dopamine pathways in electric shock reinforcement, we blocked each one of them during memory acquisition. We found that all three pathways partially contribute to electric shock memory. Notably, the memories mediated by these neurons differed in temporal stability. Furthermore, combinatorial activation of two of these pathways revealed significant interaction of individual memory components rather than their simple summation. These results cast light on a cellular mechanism by which a noxious event induces different dopamine signals to a single brain structure to synthesize an aversive memory. Public Library of Science 2012-07-12 /pmc/articles/PMC3395599/ /pubmed/22807684 http://dx.doi.org/10.1371/journal.pgen.1002768 Text en Aso et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Aso, Yoshinori
Herb, Andrea
Ogueta, Maite
Siwanowicz, Igor
Templier, Thomas
Friedrich, Anja B.
Ito, Kei
Scholz, Henrike
Tanimoto, Hiromu
Three Dopamine Pathways Induce Aversive Odor Memories with Different Stability
title Three Dopamine Pathways Induce Aversive Odor Memories with Different Stability
title_full Three Dopamine Pathways Induce Aversive Odor Memories with Different Stability
title_fullStr Three Dopamine Pathways Induce Aversive Odor Memories with Different Stability
title_full_unstemmed Three Dopamine Pathways Induce Aversive Odor Memories with Different Stability
title_short Three Dopamine Pathways Induce Aversive Odor Memories with Different Stability
title_sort three dopamine pathways induce aversive odor memories with different stability
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395599/
https://www.ncbi.nlm.nih.gov/pubmed/22807684
http://dx.doi.org/10.1371/journal.pgen.1002768
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