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Endogenous Origins of HIV-1 G-to-A Hypermutation and Restriction in the Nonpermissive T Cell Line CEM2n

The DNA deaminase APOBEC3G converts cytosines to uracils in retroviral cDNA, which are immortalized as genomic strand G-to-A hypermutations by reverse transcription. A single round of APOBEC3G-dependent mutagenesis can be catastrophic, but evidence suggests that sublethal levels contribute to viral...

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Detalles Bibliográficos
Autores principales:	Refsland, Eric W., Hultquist, Judd F., Harris, Reuben S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395617/ https://www.ncbi.nlm.nih.gov/pubmed/22807680 http://dx.doi.org/10.1371/journal.ppat.1002800

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