GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production

Proteolytic processing of the amyloid-β precursor protein (APP) and generation of amyloid-β peptide (Aβ) are key events in Alzheimer's disease (AD) pathogenesis. Cell biological and genetic evidence has implicated the low-density lipoprotein and sorting receptor LR11/SorLA in AD through mechani...

Descripción completa

Detalles Bibliográficos
Autores principales: Herskowitz, Jeremy H., Offe, Katrin, Deshpande, Aniruddha, Kahn, Richard A., Levey, Allan I., Lah, James J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395654/
https://www.ncbi.nlm.nih.gov/pubmed/22621900
http://dx.doi.org/10.1091/mbc.E12-01-0014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395654/
https://www.ncbi.nlm.nih.gov/pubmed/22621900
http://dx.doi.org/10.1091/mbc.E12-01-0014

Ejemplares similares