Cargando…

GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production

Proteolytic processing of the amyloid-β precursor protein (APP) and generation of amyloid-β peptide (Aβ) are key events in Alzheimer's disease (AD) pathogenesis. Cell biological and genetic evidence has implicated the low-density lipoprotein and sorting receptor LR11/SorLA in AD through mechani...

Descripción completa

Detalles Bibliográficos
Autores principales:	Herskowitz, Jeremy H., Offe, Katrin, Deshpande, Aniruddha, Kahn, Richard A., Levey, Allan I., Lah, James J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2012
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395654/ https://www.ncbi.nlm.nih.gov/pubmed/22621900 http://dx.doi.org/10.1091/mbc.E12-01-0014

Ejemplares similares

Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans
por: Whittle, Andrew J., et al.
Publicado: (2015)

SorLA in Interleukin-6 Signaling and Turnover
por: Larsen, Jakob Vejby, et al.
Publicado: (2017)

SorLA is a molecular link for retromer-dependent sorting of the Amyloid precursor protein
por: Fjorback, Anja W., et al.
Publicado: (2012)

Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel γ-secretase substrates
por: Nyborg, Andrew C, et al.
Publicado: (2006)

The role of SorLA in neurotrophic activity and complex behavior
por: Glerup, Simon, et al.
Publicado: (2013)

Y(682)G Mutation of Amyloid Precursor Protein Promotes Endo-Lysosomal Dysfunction by Disrupting APP–SorLA Interaction
por: La Rosa, Luca Rosario, et al.
Publicado: (2015)

Regulatory Roles of Sortilin and SorLA in Immune-Related Processes
por: Talbot, Hugo, et al.
Publicado: (2019)

SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition
por: Shih, Alexis Z.L., et al.
Publicado: (2022)

The adaptor protein PICK1 targets the sorting receptor SorLA
por: Binkle, Lars, et al.
Publicado: (2022)

HSPA12A targets the cytoplasmic domain and affects the trafficking of the Amyloid Precursor Protein receptor SorLA
por: Madsen, Peder, et al.
Publicado: (2019)

Neuronal LR11 Expression Does Not Differentiate between Clinically-Defined Alzheimer's Disease and Control Brains
por: Sager, Kristen L., et al.
Publicado: (2012)

A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance
por: Al-Akhrass, Hussein, et al.
Publicado: (2021)

Impaired SorLA maturation and trafficking as a new mechanism for SORL1 missense variants in Alzheimer disease
por: Rovelet-Lecrux, Anne, et al.
Publicado: (2021)

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry
por: Larsen, Jakob V., et al.
Publicado: (2017)

SORLA attenuates EphA4 signaling and amyloid β–induced neurodegeneration
por: Huang, Timothy Y., et al.
Publicado: (2017)

Cytokine-Like Factor 1, an Essential Facilitator of Cardiotrophin-Like Cytokine:Ciliary Neurotrophic Factor Receptor α Signaling and sorLA-Mediated Turnover
por: Larsen, Jakob Vejby, et al.
Publicado: (2016)

GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival
por: Li, Xuezhi, et al.
Publicado: (2015)

Sorting receptor SORLA: cellular mechanisms and implications for disease
por: Schmidt, Vanessa, et al.
Publicado: (2016)

Rabs, Rips, FIPs, and Endocytic Membrane Traffic
por: Prekeris, Rytis
Publicado: (2003)

SORLA regulates endosomal trafficking and oncogenic fitness of HER2
por: Pietilä, Mika, et al.
Publicado: (2019)

First-Principles Study on Electronic, Magnetic, Optical, Mechanical, and Thermodynamic Properties of Semiconducting Gadolinium Phosphide in GGA, GGA+U, mBJ, GGA+SOC and GGA+SOC+U approaches
por: Lone, Ikram Un Nabi, et al.
Publicado: (2021)

Ca(2+)-Sensor Proteins in the Autophagic and Endocytic Traffic
por: Ghislat, Ghita, et al.
Publicado: (2013)

SORLA-Mediated Trafficking of TrkB Enhances the Response of Neurons to BDNF
por: Rohe, Michael, et al.
Publicado: (2013)

Multi-compartmental modeling of SORLA’s influence on amyloidogenic processing in Alzheimer’s disease
por: Lao, Angelyn, et al.
Publicado: (2012)

Intracellular fusion of sequentially formed endocytic compartments
Publicado: (1988)

Rab 7: an important regulator of late endocytic membrane traffic
Publicado: (1995)

Local regulation of extracellular vesicle traffic by the synaptic endocytic machinery
por: Blanchette, Cassandra R., et al.
Publicado: (2022)

Assessment of endocytic traffic and Ocrl function in the developing zebrafish neuroepithelium
por: Williams, Daniel M., et al.
Publicado: (2022)

SORLA is required for insulin-induced expansion of the adipocyte precursor pool in visceral fat
por: Schmidt, Vanessa, et al.
Publicado: (2021)

Dimerization of the Alzheimer’s disease pathogenic receptor SORLA regulates its association with retromer
por: Jensen, Anne Mette G., et al.
Publicado: (2023)

Regulation of α(2B)-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2
por: Zhang, Maoxiang, et al.
Publicado: (2016)

BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice
por: Kim, WonHee, et al.
Publicado: (2018)

SorCS1 inhibits amyloid-β binding to neurexin and rescues amyloid-β–induced synaptic pathology
por: Lee, Alfred Kihoon, et al.
Publicado: (2023)

The Role of Cargo Proteins in GGA Recruitment
por: Hirst, Jennifer, et al.
Publicado: (2007)

Analysis of Gga Null Mice Demonstrates a Non-Redundant Role for Mammalian GGA2 during Development
por: Govero, Jennifer, et al.
Publicado: (2012)

Development of transgenic rats producing human β-amyloid precursor protein as a model for Alzheimer's disease: Transgene and endogenous APP genes are regulated tissue-specifically
por: Agca, Cansu, et al.
Publicado: (2008)

SOR: project methodology
por: Fervers, B, et al.
Publicado: (2001)

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism
por: Kim, Hyunho, et al.
Publicado: (2014)

ScEnSor Kit for Saccharomyces cerevisiae Engineering and Biosensor-Driven Investigation of the Intracellular Environment
por: Torello Pianale, Luca, et al.
Publicado: (2023)

The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1)
por: von Einem, Bjoern, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_mo9cjgvs772o4f47kv58s9l629