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JC Virus Leuko-Encephalopathy in Reduced Intensity Conditioning Cord Blood Transplant Recipient with a Review of the Literature

We report here the case of progressive multifocal leukoencephalopathy (PML) related to human polyomavirus JC (JCV) infection after an allogeneic transplantation with umbilical cord blood cells in 59-year-old woman with follicular Non Hodgkin lymphoma. She presented with dysphagia and weakness; magne...

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Autores principales: El-Cheikh, Jean, Fürst, Sabine, Casalonga, Francois, Crocchiolo, Roberto, Castagna, Luca, Granata, Angela, Oudin, Claire, Faucher, Catherine, Berger, Pierre, Sarran, Anthony, Blaise, Didier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Università Cattolica del Sacro Cuore 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395713/
https://www.ncbi.nlm.nih.gov/pubmed/22811792
http://dx.doi.org/10.4084/MJHID.2012.043
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author El-Cheikh, Jean
Fürst, Sabine
Casalonga, Francois
Crocchiolo, Roberto
Castagna, Luca
Granata, Angela
Oudin, Claire
Faucher, Catherine
Berger, Pierre
Sarran, Anthony
Blaise, Didier
author_facet El-Cheikh, Jean
Fürst, Sabine
Casalonga, Francois
Crocchiolo, Roberto
Castagna, Luca
Granata, Angela
Oudin, Claire
Faucher, Catherine
Berger, Pierre
Sarran, Anthony
Blaise, Didier
author_sort El-Cheikh, Jean
collection PubMed
description We report here the case of progressive multifocal leukoencephalopathy (PML) related to human polyomavirus JC (JCV) infection after an allogeneic transplantation with umbilical cord blood cells in 59-year-old woman with follicular Non Hodgkin lymphoma. She presented with dysphagia and weakness; magnetic resonance imaging demonstrated marked signal abnormality in the sub-cortical white matter of the left frontal lobe and in the posterior limb of the right internal capsule. Polymerase chain reaction (PCR) analysis of the cerebrospinal fluid (CSF) was positive for John Cunningham (JC) virus. JC viral DNA in the CSF was positive, establishing the diagnosis of PML. Brain biopsy was not done. Extensive investigations for other viral infections seen in immuno-compromised patients were negative. The patient’s neurologic deficits rapidly increased throughout her hospital stay, and she died one month after the diagnosis. These findings could have practical implications and demonstrate that in patients presenting neurological symptoms and radiological signs after UCBT, the JCV encephalitis must be early suspected.
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spelling pubmed-33957132012-07-18 JC Virus Leuko-Encephalopathy in Reduced Intensity Conditioning Cord Blood Transplant Recipient with a Review of the Literature El-Cheikh, Jean Fürst, Sabine Casalonga, Francois Crocchiolo, Roberto Castagna, Luca Granata, Angela Oudin, Claire Faucher, Catherine Berger, Pierre Sarran, Anthony Blaise, Didier Mediterr J Hematol Infect Dis Case Reports We report here the case of progressive multifocal leukoencephalopathy (PML) related to human polyomavirus JC (JCV) infection after an allogeneic transplantation with umbilical cord blood cells in 59-year-old woman with follicular Non Hodgkin lymphoma. She presented with dysphagia and weakness; magnetic resonance imaging demonstrated marked signal abnormality in the sub-cortical white matter of the left frontal lobe and in the posterior limb of the right internal capsule. Polymerase chain reaction (PCR) analysis of the cerebrospinal fluid (CSF) was positive for John Cunningham (JC) virus. JC viral DNA in the CSF was positive, establishing the diagnosis of PML. Brain biopsy was not done. Extensive investigations for other viral infections seen in immuno-compromised patients were negative. The patient’s neurologic deficits rapidly increased throughout her hospital stay, and she died one month after the diagnosis. These findings could have practical implications and demonstrate that in patients presenting neurological symptoms and radiological signs after UCBT, the JCV encephalitis must be early suspected. Università Cattolica del Sacro Cuore 2012-06-20 /pmc/articles/PMC3395713/ /pubmed/22811792 http://dx.doi.org/10.4084/MJHID.2012.043 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
El-Cheikh, Jean
Fürst, Sabine
Casalonga, Francois
Crocchiolo, Roberto
Castagna, Luca
Granata, Angela
Oudin, Claire
Faucher, Catherine
Berger, Pierre
Sarran, Anthony
Blaise, Didier
JC Virus Leuko-Encephalopathy in Reduced Intensity Conditioning Cord Blood Transplant Recipient with a Review of the Literature
title JC Virus Leuko-Encephalopathy in Reduced Intensity Conditioning Cord Blood Transplant Recipient with a Review of the Literature
title_full JC Virus Leuko-Encephalopathy in Reduced Intensity Conditioning Cord Blood Transplant Recipient with a Review of the Literature
title_fullStr JC Virus Leuko-Encephalopathy in Reduced Intensity Conditioning Cord Blood Transplant Recipient with a Review of the Literature
title_full_unstemmed JC Virus Leuko-Encephalopathy in Reduced Intensity Conditioning Cord Blood Transplant Recipient with a Review of the Literature
title_short JC Virus Leuko-Encephalopathy in Reduced Intensity Conditioning Cord Blood Transplant Recipient with a Review of the Literature
title_sort jc virus leuko-encephalopathy in reduced intensity conditioning cord blood transplant recipient with a review of the literature
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395713/
https://www.ncbi.nlm.nih.gov/pubmed/22811792
http://dx.doi.org/10.4084/MJHID.2012.043
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