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Conventional epidemiology underestimates the incidence of asthma and wheeze-a longitudinal population-based study among teenagers

BACKGROUND: Because of shifts in the gender ratio and incidence and remission rates of asthma during the teen ages, the methodology of incidence studies among teenagers is important, i.e. if the time intervals between surveys are too long, the incident cases might not be properly identified. The aim...

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Autores principales: Hedman, Linnéa, Bjerg, Anders, Lundbäck, Bo, Rönmark, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395824/
https://www.ncbi.nlm.nih.gov/pubmed/22409857
http://dx.doi.org/10.1186/2045-7022-2-1
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author Hedman, Linnéa
Bjerg, Anders
Lundbäck, Bo
Rönmark, Eva
author_facet Hedman, Linnéa
Bjerg, Anders
Lundbäck, Bo
Rönmark, Eva
author_sort Hedman, Linnéa
collection PubMed
description BACKGROUND: Because of shifts in the gender ratio and incidence and remission rates of asthma during the teen ages, the methodology of incidence studies among teenagers is important, i.e. if the time intervals between surveys are too long, the incident cases might not be properly identified. The aim was to study the impact of study design on the incidence rates of asthma and wheeze during the teen ages. METHODS: In a study about asthma and allergic diseases within the OLIN studies (Obstructive Lung Disease in northern Sweden), a cohort of school children (n = 3,430) was followed annually by questionnaire from age 8 yrs. In the endpoint survey (age 18 yrs) 2,582 (75% of original responders) participated. Incident cases from age 12-18 yrs were identified by two methods: annual questionnaire reports (AR) and baseline-endpoint surveys only (BE). RESULTS: The cumulative incidence of asthma and wheeze was significantly higher based on AR compared to BE. Compared to the incidence rates based on all the annual surveys, the calculated average annual rates based on BE were in general lower both among the boys and among the girls. There were no differences between boys and girls in incidence rates of asthma or wheeze during the early teen years. However, from the age of 15 years, the annual incidence rates were significantly or borderline significantly higher among girls than boys. At onset, the additional cases of current asthma identified by AR had significantly less severe asthma than those identified in BE (p < 0.02). CONCLUSION: the size of the incidence of asthma and wheeze during the teen ages was influenced by study design. By using the conventional prospective study design with longer follow-up time, the incidence was underestimated.
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spelling pubmed-33958242012-07-16 Conventional epidemiology underestimates the incidence of asthma and wheeze-a longitudinal population-based study among teenagers Hedman, Linnéa Bjerg, Anders Lundbäck, Bo Rönmark, Eva Clin Transl Allergy Research BACKGROUND: Because of shifts in the gender ratio and incidence and remission rates of asthma during the teen ages, the methodology of incidence studies among teenagers is important, i.e. if the time intervals between surveys are too long, the incident cases might not be properly identified. The aim was to study the impact of study design on the incidence rates of asthma and wheeze during the teen ages. METHODS: In a study about asthma and allergic diseases within the OLIN studies (Obstructive Lung Disease in northern Sweden), a cohort of school children (n = 3,430) was followed annually by questionnaire from age 8 yrs. In the endpoint survey (age 18 yrs) 2,582 (75% of original responders) participated. Incident cases from age 12-18 yrs were identified by two methods: annual questionnaire reports (AR) and baseline-endpoint surveys only (BE). RESULTS: The cumulative incidence of asthma and wheeze was significantly higher based on AR compared to BE. Compared to the incidence rates based on all the annual surveys, the calculated average annual rates based on BE were in general lower both among the boys and among the girls. There were no differences between boys and girls in incidence rates of asthma or wheeze during the early teen years. However, from the age of 15 years, the annual incidence rates were significantly or borderline significantly higher among girls than boys. At onset, the additional cases of current asthma identified by AR had significantly less severe asthma than those identified in BE (p < 0.02). CONCLUSION: the size of the incidence of asthma and wheeze during the teen ages was influenced by study design. By using the conventional prospective study design with longer follow-up time, the incidence was underestimated. BioMed Central 2012-01-04 /pmc/articles/PMC3395824/ /pubmed/22409857 http://dx.doi.org/10.1186/2045-7022-2-1 Text en Copyright ©2012 Hedman et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Hedman, Linnéa
Bjerg, Anders
Lundbäck, Bo
Rönmark, Eva
Conventional epidemiology underestimates the incidence of asthma and wheeze-a longitudinal population-based study among teenagers
title Conventional epidemiology underestimates the incidence of asthma and wheeze-a longitudinal population-based study among teenagers
title_full Conventional epidemiology underestimates the incidence of asthma and wheeze-a longitudinal population-based study among teenagers
title_fullStr Conventional epidemiology underestimates the incidence of asthma and wheeze-a longitudinal population-based study among teenagers
title_full_unstemmed Conventional epidemiology underestimates the incidence of asthma and wheeze-a longitudinal population-based study among teenagers
title_short Conventional epidemiology underestimates the incidence of asthma and wheeze-a longitudinal population-based study among teenagers
title_sort conventional epidemiology underestimates the incidence of asthma and wheeze-a longitudinal population-based study among teenagers
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395824/
https://www.ncbi.nlm.nih.gov/pubmed/22409857
http://dx.doi.org/10.1186/2045-7022-2-1
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