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Predict impact of single amino acid change upon protein structure

BACKGROUND: Amino acid point mutations (nsSNPs) may change protein structure and function. However, no method directly predicts the impact of mutations on structure. Here, we compare pairs of pentamers (five consecutive residues) that locally change protein three-dimensional structure (3D, RMSD>0...

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Detalles Bibliográficos
Autores principales:	Schaefer, Christian, Rost, Burkhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Proceedings
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395892/ https://www.ncbi.nlm.nih.gov/pubmed/22759652 http://dx.doi.org/10.1186/1471-2164-13-S4-S4

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