A placebo-controlled, double-blind, dose-escalation study to assess the safety, tolerability and pharmacokinetics/pharmacodynamics of single and multiple intravenous infusions of AZD9773 in patients with severe sepsis and septic shock

INTRODUCTION: Tumor necrosis factor-alpha (TNF-α), an early mediator in the systemic inflammatory response to infection, is a potential therapeutic target in sepsis. The primary objective of this study was to determine the safety and tolerability of AZD9773, an ovine, polyclonal, anti-human TNF-α Fa...

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Detalles Bibliográficos
Autores principales: Morris, Peter E, Zeno, Brian, Bernard, Andrew C, Huang, Xiangning, Das, Shampa, Edeki, Timi, Simonson, Steven G, Bernard, Gordon R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396277/
https://www.ncbi.nlm.nih.gov/pubmed/22340283
http://dx.doi.org/10.1186/cc11203

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