Preparation of an antitumor and antivirus agent: chemical modification of α-MMC and MAP30 from Momordica Charantia L. with covalent conjugation of polyethyelene glycol

BACKGROUND: Alpha-momorcharin (α-MMC) and momordica anti-HIV protein (MAP30) derived from Momordica charantia L. have been confirmed to possess antitumor and antivirus activities due to their RNA-N-glycosidase activity. However, strong immunogenicity and short plasma half-life limit their clinical a...

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Detalles Bibliográficos
Autores principales: Meng, Yao, Liu, Shuangfeng, Li, Juan, Meng, Yanfa, Zhao, Xiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396394/
https://www.ncbi.nlm.nih.gov/pubmed/22802682
http://dx.doi.org/10.2147/IJN.S30631

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