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Iontophoresis of Endothelin Receptor Antagonists in Rats and Men

INTRODUCTION: The treatment of scleroderma-related digital ulcers is challenging. The oral endothelin receptor antagonist (ERA) bosentan has been approved but it may induce liver toxicity. The objective of this study was to test whether ERAs bosentan and sitaxentan could be locally delivered using i...

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Detalles Bibliográficos
Autores principales:	Roustit, Matthieu, Blaise, Sophie, Arnaud, Claire, Hellmann, Marcin, Millet, Claire, Godin-Ribuot, Diane, Dufournet, Boris, Boutonnat, Jean, Ribuot, Christophe, Cracowski, Jean-Luc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396598/ https://www.ncbi.nlm.nih.gov/pubmed/22808263 http://dx.doi.org/10.1371/journal.pone.0040792

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