Cargando…

The Functional Interaction between Acyl-CoA Synthetase 4, 5-Lipooxygenase and Cyclooxygenase-2 Controls Tumor Growth: A Novel Therapeutic Target

The acyl-CoA synthetase 4 (ACSL4), which esterify mainly arachidonic acid (AA) into acyl-CoA, is increased in breast, colon and hepatocellular carcinoma. The transfection of MCF-7 cells with ACSL4 cDNA transforms the cells into a highly aggressive phenotype and controls both lipooxygenase-5 (LOX-5)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Orlando, Ulises D., Garona, Juan, Ripoll, Giselle V., Maloberti, Paula M., Solano, Ángela R., Avagnina, Alejandra, Gomez, Daniel E., Alonso, Daniel F., Podestá, Ernesto J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396606/ https://www.ncbi.nlm.nih.gov/pubmed/22808264 http://dx.doi.org/10.1371/journal.pone.0040794

Ejemplares similares

Functional Interaction between Acyl-CoA Synthetase 4, Lipooxygenases and Cyclooxygenase-2 in the Aggressive Phenotype of Breast Cancer Cells
por: Maloberti, Paula M., et al.
Publicado: (2010)

Regulatory mechanisms leading to differential Acyl-CoA synthetase 4 expression in breast cancer cells
por: Dattilo, Melina A., et al.
Publicado: (2019)

Acyl-CoA synthetase-4, a new regulator of mTOR and a potential therapeutic target for enhanced estrogen receptor function in receptor-positive and -negative breast cancer
por: Orlando, Ulises D., et al.
Publicado: (2015)

The novel desmopressin analogue [V(4)Q(5)]dDAVP inhibits angiogenesis, tumour growth and metastases in vasopressin type 2 receptor-expressing breast cancer models
por: GARONA, JUAN, et al.
Publicado: (2015)

An Acyl-CoA Synthetase in Mycobacterium tuberculosis Involved in Triacylglycerol Accumulation during Dormancy
por: Daniel, Jaiyanth, et al.
Publicado: (2014)

Giardia fatty acyl-CoA synthetases as potential drug targets
por: Guo, Fengguang, et al.
Publicado: (2015)

Targeting Long Chain Acyl-CoA Synthetases for Cancer Therapy
por: Rossi Sebastiano, Matteo, et al.
Publicado: (2019)

Long-Chain Acyl-CoA Synthetase is Associated with the Growth of Malassezia spp.
por: Tenagy,, et al.
Publicado: (2019)

Fatty acid metabolism and acyl-CoA synthetases in the liver-gut axis
por: Ma, Yunxia, et al.
Publicado: (2021)

Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains
por: Kassan, Adam, et al.
Publicado: (2013)

Long-chain bases of sphingolipids are transported into cells via the acyl-CoA synthetases
por: Narita, Tomomi, et al.
Publicado: (2016)

Acyl-CoA Synthetase 5 Promotes the Growth and Invasion of Colorectal Cancer Cells
por: Ding, Shihua, et al.
Publicado: (2017)

Diversity and history of the long-chain acyl-CoA synthetase (Acsl) gene family in vertebrates
por: Lopes-Marques, Mónica, et al.
Publicado: (2013)

The acyl-CoA Synthetase, pudgy, Promotes Sleep and Is Required for the Homeostatic Response to Sleep Deprivation
por: Thimgan, Matthew S., et al.
Publicado: (2018)

Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane composition and fluidity
por: Ruiz, Mario, et al.
Publicado: (2019)

Functional Role of Long-Chain Acyl-CoA Synthetases in Plant Development and Stress Responses
por: Zhao, Huayan, et al.
Publicado: (2021)

Acyl‐CoA synthetase expression in human skeletal muscle is reduced in obesity and insulin resistance
por: Poppelreuther, Margarete, et al.
Publicado: (2023)

Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation
por: Bopp, Selina, et al.
Publicado: (2023)

Commentary: Arginine vasopressin receptor 1a is a therapeutic target for castration-resistant prostate cancer
por: Ripoll, Giselle V., et al.
Publicado: (2020)

Activity of the acyl-CoA synthetase ACSL6 isoforms: role of the fatty acid Gate-domains
por: Soupene, Eric, et al.
Publicado: (2010)

Outlook: membrane junctions enable the metabolic trapping of fatty acids by intracellular acyl-CoA synthetases
por: Füllekrug, Joachim, et al.
Publicado: (2012)

Very Long-Chain Acyl-CoA Synthetase 3: Overexpression and Growth Dependence in Lung Cancer
por: Pei, Zhengtong, et al.
Publicado: (2013)

Neurodegeneration in a Drosophila model of adrenoleukodystrophy: the roles of the Bubblegum and Double bubble acyl-CoA synthetases
por: Sivachenko, Anna, et al.
Publicado: (2016)

Characterization of Ten Heterotetrameric NDP-Dependent Acyl-CoA Synthetases of the Hyperthermophilic Archaeon Pyrococcus furiosus
por: Scott, Joseph W., et al.
Publicado: (2014)

Regulated Acyl-CoA Synthetase Short-Chain Family Member 2 Accumulation during Spermatogenesis
por: Goudarzi, Afsaneh, et al.
Publicado: (2020)

Long-chain acyl-CoA synthetase 2 is involved in seed oil production in Brassica napus
por: Ding, Li-Na, et al.
Publicado: (2020)

Acyl-CoA synthetase 6 is required for brain docosahexaenoic acid retention and neuroprotection during aging
por: Fernandez, Regina F., et al.
Publicado: (2021)

The Roles of Coenzyme A Binding Pocket Residues in Short and Medium Chain Acyl-CoA Synthetases
por: Meng, Yu, et al.
Publicado: (2023)

Lipooxygenase inhibition in osteoarthritis: a potential symptomatic and disease modifying effect?
por: Dougados, Maxime
Publicado: (2008)

Arachidonic acid downregulates acyl-CoA synthetase 4 expression by promoting its ubiquitination and proteasomal degradation
por: Kan, Chin Fung Kelvin, et al.
Publicado: (2014)

A Peroxisomal Long-Chain Acyl-CoA Synthetase from Glycine max Involved in Lipid Degradation
por: Yu, Lili, et al.
Publicado: (2014)

Enhancement of E. coli acyl-CoA synthetase FadD activity on medium chain fatty acids
por: Ford, Tyler J., et al.
Publicado: (2015)

Chlamydia trachomatis growth and development requires the activity of host Long-chain Acyl-CoA Synthetases (ACSLs)
por: Recuero-Checa, Maria A., et al.
Publicado: (2016)

The effect of acyl-CoA synthetase long-chain family member 5 on triglyceride synthesis in bovine preadipocytes
por: Yu, Xiang, et al.
Publicado: (2019)

Solution and Membrane Interaction Dynamics of Mycobacterium tuberculosis Fatty Acyl-CoA Synthetase FadD13
por: Lundgren, Camilla A. K., et al.
Publicado: (2021)

Reduction of tumor angiogenesis induced by desmopressin in a breast cancer model
por: Ripoll, Giselle V., et al.
Publicado: (2013)

Identification of the kinetic mechanism of succinyl-CoA synthetase
por: Li, Xin, et al.
Publicado: (2013)

Multiple FadD Acyl-CoA Synthetases Contribute to Differential Fatty Acid Degradation and Virulence in Pseudomonas aeruginosa
por: Kang, Yun, et al.
Publicado: (2010)

Elucidating the Pseudomonas aeruginosa Fatty Acid Degradation Pathway: Identification of Additional Fatty Acyl-CoA Synthetase Homologues
por: Zarzycki-Siek, Jan, et al.
Publicado: (2013)

Modulation of long-chain Acyl-CoA synthetase on the development, lipid deposit and cryosurvival of in vitro produced bovine embryos
por: Valente, Roniele Santana, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_78qs70r21voikjubj1ubc6o5a3