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High Passage MIN6 Cells Have Impaired Insulin Secretion with Impaired Glucose and Lipid Oxidation

Type 2 diabetes is a metabolic disorder characterized by the inability of beta-cells to secrete enough insulin to maintain glucose homeostasis. MIN6 cells secrete insulin in response to glucose and other secretagogues, but high passage (HP) MIN6 cells lose their ability to secrete insulin in respons...

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Detalles Bibliográficos
Autores principales:	Cheng, Kim, Delghingaro-Augusto, Viviane, Nolan, Christopher J., Turner, Nigel, Hallahan, Nicole, Andrikopoulos, Sofianos, Gunton, Jenny E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396628/ https://www.ncbi.nlm.nih.gov/pubmed/22808281 http://dx.doi.org/10.1371/journal.pone.0040868

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