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H(2)O(2) Production Downstream of FLT3 Is Mediated by p22phox in the Endoplasmic Reticulum and Is Required for STAT5 Signalling

The internal tandem duplication (ITD) of the juxtamembrane region of the FLT3 receptor has been associated with increased reactive oxygen species (ROS) generation in acute myeloid leukemia (AML). How this elevated level of ROS contributes to the leukemic phenotype, however, remains poorly understood...

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Detalles Bibliográficos
Autores principales:	Woolley, John F., Naughton, Ruth, Stanicka, Joanna, Gough, David R., Bhatt, Lavinia, Dickinson, Bryan C., Chang, Christopher J., Cotter, Thomas G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396659/ https://www.ncbi.nlm.nih.gov/pubmed/22807997 http://dx.doi.org/10.1371/journal.pone.0034050

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