Next generation of non-mammalian blood-brain barrier models to study parasitic infections of the central nervous system

Transmigration of neuropathogens across the blood-brain barrier is a key step in the development of central nervous system infections, making it a prime target for drug development. The ability of neuropathogens to traverse the blood-brain barrier continues to inspire researchers to understand the s...

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Autores principales: Siddiqui, Ruqaiyyah, Edwards-Smallbone, James, Flynn, Robin, Khan, Naveed Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396694/
https://www.ncbi.nlm.nih.gov/pubmed/21921682
http://dx.doi.org/10.4161/viru.17631
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author Siddiqui, Ruqaiyyah
Edwards-Smallbone, James
Flynn, Robin
Khan, Naveed Ahmed
author_facet Siddiqui, Ruqaiyyah
Edwards-Smallbone, James
Flynn, Robin
Khan, Naveed Ahmed
author_sort Siddiqui, Ruqaiyyah
collection PubMed
description Transmigration of neuropathogens across the blood-brain barrier is a key step in the development of central nervous system infections, making it a prime target for drug development. The ability of neuropathogens to traverse the blood-brain barrier continues to inspire researchers to understand the specific strategies and molecular mechanisms that allow them to enter the brain. The availability of models of the blood-brain barrier that closely mimic the situation in vivo offers unprecedented opportunities for the development of novel therapeutics.
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spelling pubmed-33966942012-07-16 Next generation of non-mammalian blood-brain barrier models to study parasitic infections of the central nervous system Siddiqui, Ruqaiyyah Edwards-Smallbone, James Flynn, Robin Khan, Naveed Ahmed Virulence Review Transmigration of neuropathogens across the blood-brain barrier is a key step in the development of central nervous system infections, making it a prime target for drug development. The ability of neuropathogens to traverse the blood-brain barrier continues to inspire researchers to understand the specific strategies and molecular mechanisms that allow them to enter the brain. The availability of models of the blood-brain barrier that closely mimic the situation in vivo offers unprecedented opportunities for the development of novel therapeutics. Landes Bioscience 2012-03-01 /pmc/articles/PMC3396694/ /pubmed/21921682 http://dx.doi.org/10.4161/viru.17631 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Siddiqui, Ruqaiyyah
Edwards-Smallbone, James
Flynn, Robin
Khan, Naveed Ahmed
Next generation of non-mammalian blood-brain barrier models to study parasitic infections of the central nervous system
title Next generation of non-mammalian blood-brain barrier models to study parasitic infections of the central nervous system
title_full Next generation of non-mammalian blood-brain barrier models to study parasitic infections of the central nervous system
title_fullStr Next generation of non-mammalian blood-brain barrier models to study parasitic infections of the central nervous system
title_full_unstemmed Next generation of non-mammalian blood-brain barrier models to study parasitic infections of the central nervous system
title_short Next generation of non-mammalian blood-brain barrier models to study parasitic infections of the central nervous system
title_sort next generation of non-mammalian blood-brain barrier models to study parasitic infections of the central nervous system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396694/
https://www.ncbi.nlm.nih.gov/pubmed/21921682
http://dx.doi.org/10.4161/viru.17631
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