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Blood-brain barrier and retroviral infections
Homeostasis in the central nervous system (CNS) is maintained by active interfaces between the bloodstream and the brain parenchyma. The blood-brain barrier (BBB) constitutes a selective filter for exchange of water, solutes, nutrients, and controls toxic compounds or pathogens entry. Some parasites...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396701/ https://www.ncbi.nlm.nih.gov/pubmed/22460635 http://dx.doi.org/10.4161/viru.19697 |
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author | Miller, Florence Afonso, Philippe V. Gessain, Antoine Ceccaldi, Pierre-Emmanuel |
author_facet | Miller, Florence Afonso, Philippe V. Gessain, Antoine Ceccaldi, Pierre-Emmanuel |
author_sort | Miller, Florence |
collection | PubMed |
description | Homeostasis in the central nervous system (CNS) is maintained by active interfaces between the bloodstream and the brain parenchyma. The blood-brain barrier (BBB) constitutes a selective filter for exchange of water, solutes, nutrients, and controls toxic compounds or pathogens entry. Some parasites, bacteria, and viruses have however developed various CNS invasion strategies, and can bypass the brain barriers. Concerning viruses, these strategies include transport along neural pathways, transcytosis, infection of the brain endothelial cells, breaching of the BBB, and passage of infected-leukocytes. Moreover, neurotropic viruses can alter BBB functions, thus compromising CNS homeostasis. Retroviruses have been associated to human neurological diseases: HIV (human immunodeficiency virus 1) can induce HIV-associated dementia, and HTLV-1 (human T lymphotropic virus 1) is the etiological factor of tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM). The present review focuses on how the different retroviruses interact with this structure, bypass it and alter its functions. |
format | Online Article Text |
id | pubmed-3396701 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-33967012012-07-16 Blood-brain barrier and retroviral infections Miller, Florence Afonso, Philippe V. Gessain, Antoine Ceccaldi, Pierre-Emmanuel Virulence Review Homeostasis in the central nervous system (CNS) is maintained by active interfaces between the bloodstream and the brain parenchyma. The blood-brain barrier (BBB) constitutes a selective filter for exchange of water, solutes, nutrients, and controls toxic compounds or pathogens entry. Some parasites, bacteria, and viruses have however developed various CNS invasion strategies, and can bypass the brain barriers. Concerning viruses, these strategies include transport along neural pathways, transcytosis, infection of the brain endothelial cells, breaching of the BBB, and passage of infected-leukocytes. Moreover, neurotropic viruses can alter BBB functions, thus compromising CNS homeostasis. Retroviruses have been associated to human neurological diseases: HIV (human immunodeficiency virus 1) can induce HIV-associated dementia, and HTLV-1 (human T lymphotropic virus 1) is the etiological factor of tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM). The present review focuses on how the different retroviruses interact with this structure, bypass it and alter its functions. Landes Bioscience 2012-03-01 /pmc/articles/PMC3396701/ /pubmed/22460635 http://dx.doi.org/10.4161/viru.19697 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Review Miller, Florence Afonso, Philippe V. Gessain, Antoine Ceccaldi, Pierre-Emmanuel Blood-brain barrier and retroviral infections |
title | Blood-brain barrier and retroviral infections |
title_full | Blood-brain barrier and retroviral infections |
title_fullStr | Blood-brain barrier and retroviral infections |
title_full_unstemmed | Blood-brain barrier and retroviral infections |
title_short | Blood-brain barrier and retroviral infections |
title_sort | blood-brain barrier and retroviral infections |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396701/ https://www.ncbi.nlm.nih.gov/pubmed/22460635 http://dx.doi.org/10.4161/viru.19697 |
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