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Synthetic constructs in/for the environment: Managing the interplay between natural and engineered Biology
The plausible release of deeply engineered or even entirely synthetic/artificial microorganisms raises the issue of their intentional (e.g. bioremediation) or accidental interaction with the Environment. Containment systems designed in the 1980s–1990s for limiting the spread of genetically engineere...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396840/ https://www.ncbi.nlm.nih.gov/pubmed/22710182 http://dx.doi.org/10.1016/j.febslet.2012.02.022 |
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author | Schmidt, Markus de Lorenzo, Víctor |
author_facet | Schmidt, Markus de Lorenzo, Víctor |
author_sort | Schmidt, Markus |
collection | PubMed |
description | The plausible release of deeply engineered or even entirely synthetic/artificial microorganisms raises the issue of their intentional (e.g. bioremediation) or accidental interaction with the Environment. Containment systems designed in the 1980s–1990s for limiting the spread of genetically engineered bacteria and their recombinant traits are still applicable to contemporary Synthetic Biology constructs. Yet, the ease of DNA synthesis and the uncertainty on how non‐natural properties and strains could interplay with the existing biological word poses yet again the challenge of designing safe and efficacious firewalls to curtail possible interactions. Such barriers may include xeno‐nucleic acids (XNAs) instead of DNA as information‐bearing molecules, rewriting the genetic code to make it non‐understandable by the existing gene expression machineries, and/or making growth dependent on xenobiotic chemicals. |
format | Online Article Text |
id | pubmed-3396840 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-33968402012-07-24 Synthetic constructs in/for the environment: Managing the interplay between natural and engineered Biology Schmidt, Markus de Lorenzo, Víctor FEBS Lett Reviews The plausible release of deeply engineered or even entirely synthetic/artificial microorganisms raises the issue of their intentional (e.g. bioremediation) or accidental interaction with the Environment. Containment systems designed in the 1980s–1990s for limiting the spread of genetically engineered bacteria and their recombinant traits are still applicable to contemporary Synthetic Biology constructs. Yet, the ease of DNA synthesis and the uncertainty on how non‐natural properties and strains could interplay with the existing biological word poses yet again the challenge of designing safe and efficacious firewalls to curtail possible interactions. Such barriers may include xeno‐nucleic acids (XNAs) instead of DNA as information‐bearing molecules, rewriting the genetic code to make it non‐understandable by the existing gene expression machineries, and/or making growth dependent on xenobiotic chemicals. John Wiley and Sons Inc. 2012-07-16 2012-02-23 /pmc/articles/PMC3396840/ /pubmed/22710182 http://dx.doi.org/10.1016/j.febslet.2012.02.022 Text en FEBS Letters 586 (2012) 0014-5793 ©2015 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Reviews Schmidt, Markus de Lorenzo, Víctor Synthetic constructs in/for the environment: Managing the interplay between natural and engineered Biology |
title | Synthetic constructs in/for the environment: Managing the interplay between natural and engineered Biology |
title_full | Synthetic constructs in/for the environment: Managing the interplay between natural and engineered Biology |
title_fullStr | Synthetic constructs in/for the environment: Managing the interplay between natural and engineered Biology |
title_full_unstemmed | Synthetic constructs in/for the environment: Managing the interplay between natural and engineered Biology |
title_short | Synthetic constructs in/for the environment: Managing the interplay between natural and engineered Biology |
title_sort | synthetic constructs in/for the environment: managing the interplay between natural and engineered biology |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396840/ https://www.ncbi.nlm.nih.gov/pubmed/22710182 http://dx.doi.org/10.1016/j.febslet.2012.02.022 |
work_keys_str_mv | AT schmidtmarkus syntheticconstructsinfortheenvironmentmanagingtheinterplaybetweennaturalandengineeredbiology AT delorenzovictor syntheticconstructsinfortheenvironmentmanagingtheinterplaybetweennaturalandengineeredbiology |