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Comparison of Quantiferon Test with Tuberculin Skin Test for the Detection of Tuberculosis Infection in Children
The efficacy of Quantiferon-TB gold test (QFT-GIT) remains to be documented in pediatric population. Tuberculin skin test (TST) is a conventional test available for the diagnosis of latent tuberculosis infection (LTBI). We aimed to investigate the concordance between QFT-GIT and TST in children with...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397234/ https://www.ncbi.nlm.nih.gov/pubmed/22535495 http://dx.doi.org/10.1007/s10753-012-9466-1 |
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author | Onur, Hatice Hatipoğlu, Sami Arıca, Vefik Hatipoğlu, Nevin Arıca, Seçil Gunher |
author_facet | Onur, Hatice Hatipoğlu, Sami Arıca, Vefik Hatipoğlu, Nevin Arıca, Seçil Gunher |
author_sort | Onur, Hatice |
collection | PubMed |
description | The efficacy of Quantiferon-TB gold test (QFT-GIT) remains to be documented in pediatric population. Tuberculin skin test (TST) is a conventional test available for the diagnosis of latent tuberculosis infection (LTBI). We aimed to investigate the concordance between QFT-GIT and TST in children with and without tuberculosis infection. Ninety-seven patients, aged 3 months–14 years, admitted to pediatric outpatient clinics of Dr. Sadi Konuk Training Hospital Bakırköy, Turkey between March 2008 and April 2009 were recruited. Demographic features, TST results, history of exposure to active tuberculosis (TB), chest X-ray findings, clinical history, presence of Bacillus Calmette Guerin (BCG) vaccination scar were recorded. Patients were categorized into four groups namely, active TB, LTBI, no TB and healthy. It was found that BCG scar positivity did not influence QFT-GIT results. There was a statistically significant agreement between QFT-GIT and TST results (κ = 0.486; p < 0.01). In patients ≥5 years of age, TST positivity and QFT positivity had a significant relationship (p < 0.01). In all patient groups, sensitivity and specificity was 65.85 % and 82.14 %, respectively. In active TB group, TST and QFT-GIT results demonstrated significant agreement ratio of 40.8 % (κ = 0.364; p < 0.01). Sensitivity and specificity was 100 % and 30 %, respectively. Utilization of QFT-GIT in the diagnosis of LTBI reduces false-positive results and prevents unnecessary treatment with INH and its adverse effects. |
format | Online Article Text |
id | pubmed-3397234 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-33972342012-07-23 Comparison of Quantiferon Test with Tuberculin Skin Test for the Detection of Tuberculosis Infection in Children Onur, Hatice Hatipoğlu, Sami Arıca, Vefik Hatipoğlu, Nevin Arıca, Seçil Gunher Inflammation Article The efficacy of Quantiferon-TB gold test (QFT-GIT) remains to be documented in pediatric population. Tuberculin skin test (TST) is a conventional test available for the diagnosis of latent tuberculosis infection (LTBI). We aimed to investigate the concordance between QFT-GIT and TST in children with and without tuberculosis infection. Ninety-seven patients, aged 3 months–14 years, admitted to pediatric outpatient clinics of Dr. Sadi Konuk Training Hospital Bakırköy, Turkey between March 2008 and April 2009 were recruited. Demographic features, TST results, history of exposure to active tuberculosis (TB), chest X-ray findings, clinical history, presence of Bacillus Calmette Guerin (BCG) vaccination scar were recorded. Patients were categorized into four groups namely, active TB, LTBI, no TB and healthy. It was found that BCG scar positivity did not influence QFT-GIT results. There was a statistically significant agreement between QFT-GIT and TST results (κ = 0.486; p < 0.01). In patients ≥5 years of age, TST positivity and QFT positivity had a significant relationship (p < 0.01). In all patient groups, sensitivity and specificity was 65.85 % and 82.14 %, respectively. In active TB group, TST and QFT-GIT results demonstrated significant agreement ratio of 40.8 % (κ = 0.364; p < 0.01). Sensitivity and specificity was 100 % and 30 %, respectively. Utilization of QFT-GIT in the diagnosis of LTBI reduces false-positive results and prevents unnecessary treatment with INH and its adverse effects. Springer US 2012-04-26 2012 /pmc/articles/PMC3397234/ /pubmed/22535495 http://dx.doi.org/10.1007/s10753-012-9466-1 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Article Onur, Hatice Hatipoğlu, Sami Arıca, Vefik Hatipoğlu, Nevin Arıca, Seçil Gunher Comparison of Quantiferon Test with Tuberculin Skin Test for the Detection of Tuberculosis Infection in Children |
title | Comparison of Quantiferon Test with Tuberculin Skin Test for the Detection of Tuberculosis Infection in Children |
title_full | Comparison of Quantiferon Test with Tuberculin Skin Test for the Detection of Tuberculosis Infection in Children |
title_fullStr | Comparison of Quantiferon Test with Tuberculin Skin Test for the Detection of Tuberculosis Infection in Children |
title_full_unstemmed | Comparison of Quantiferon Test with Tuberculin Skin Test for the Detection of Tuberculosis Infection in Children |
title_short | Comparison of Quantiferon Test with Tuberculin Skin Test for the Detection of Tuberculosis Infection in Children |
title_sort | comparison of quantiferon test with tuberculin skin test for the detection of tuberculosis infection in children |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397234/ https://www.ncbi.nlm.nih.gov/pubmed/22535495 http://dx.doi.org/10.1007/s10753-012-9466-1 |
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