Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex

Four new eunicellin-based diterpenes, simplexins P–S (1–4), and the known compound simplexin A (5), have been isolated from the soft coral Klyxum simplex. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly 1D and 2D NMR experiments. C...

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Autores principales: Wu, Shwu-Li, Su, Jui-Hsin, Huang, Chiung-Yao, Tai, Chi-Jen, Sung, Ping-Jyun, Liaw, Chih-Chung, Sheu, Jyh-Horng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397434/
https://www.ncbi.nlm.nih.gov/pubmed/22822367
http://dx.doi.org/10.3390/md10061203
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author Wu, Shwu-Li
Su, Jui-Hsin
Huang, Chiung-Yao
Tai, Chi-Jen
Sung, Ping-Jyun
Liaw, Chih-Chung
Sheu, Jyh-Horng
author_facet Wu, Shwu-Li
Su, Jui-Hsin
Huang, Chiung-Yao
Tai, Chi-Jen
Sung, Ping-Jyun
Liaw, Chih-Chung
Sheu, Jyh-Horng
author_sort Wu, Shwu-Li
collection PubMed
description Four new eunicellin-based diterpenes, simplexins P–S (1–4), and the known compound simplexin A (5), have been isolated from the soft coral Klyxum simplex. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly 1D and 2D NMR experiments. Compounds 1 and 3–5 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines, 3 being the most cytotoxic.
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spelling pubmed-33974342012-07-20 Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex Wu, Shwu-Li Su, Jui-Hsin Huang, Chiung-Yao Tai, Chi-Jen Sung, Ping-Jyun Liaw, Chih-Chung Sheu, Jyh-Horng Mar Drugs Article Four new eunicellin-based diterpenes, simplexins P–S (1–4), and the known compound simplexin A (5), have been isolated from the soft coral Klyxum simplex. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly 1D and 2D NMR experiments. Compounds 1 and 3–5 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines, 3 being the most cytotoxic. MDPI 2012-05-25 /pmc/articles/PMC3397434/ /pubmed/22822367 http://dx.doi.org/10.3390/md10061203 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wu, Shwu-Li
Su, Jui-Hsin
Huang, Chiung-Yao
Tai, Chi-Jen
Sung, Ping-Jyun
Liaw, Chih-Chung
Sheu, Jyh-Horng
Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex
title Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex
title_full Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex
title_fullStr Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex
title_full_unstemmed Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex
title_short Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex
title_sort simplexins p–s, eunicellin-based diterpenes from the soft coral klyxum simplex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397434/
https://www.ncbi.nlm.nih.gov/pubmed/22822367
http://dx.doi.org/10.3390/md10061203
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