Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways

Cyclotripeptide X-13 is a core of novel marine compound xyloallenoide A isolated from mangrove fungus Xylaria sp. (no. 2508). We found that X-13 dose-dependently induced angiogenesis in zebrafish embryos and in human endothelial cells, which was accompanied by increased phosphorylation of eNOS and A...

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Detalles Bibliográficos
Autores principales: Lu, Xi-Lin, Xu, Zhong-Liang, Yao, Xiao-Li, Su, Feng-Juan, Ye, Cheng-Hui, Li, Jing, Lin, Yong-Cheng, Wang, Guang-Lei, Zeng, Jin-Sheng, Huang, Ru-Xun, Ou, Jing-Song, Sun, Hong-Shuo, Wang, Li-Ping, Pang, Ji-Yan, Pei, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397441/
https://www.ncbi.nlm.nih.gov/pubmed/22822374
http://dx.doi.org/10.3390/md10061307
Descripción
Sumario:Cyclotripeptide X-13 is a core of novel marine compound xyloallenoide A isolated from mangrove fungus Xylaria sp. (no. 2508). We found that X-13 dose-dependently induced angiogenesis in zebrafish embryos and in human endothelial cells, which was accompanied by increased phosphorylation of eNOS and Akt and NO release. Inhibition of PI3K/Akt/eNOS by LY294002 or L-NAME suppressed X-13-induced angiogenesis. The present work demonstrates that X-13 promotes angiogenesis via PI3K/Akt/eNOS pathways.

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