Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways

Cyclotripeptide X-13 is a core of novel marine compound xyloallenoide A isolated from mangrove fungus Xylaria sp. (no. 2508). We found that X-13 dose-dependently induced angiogenesis in zebrafish embryos and in human endothelial cells, which was accompanied by increased phosphorylation of eNOS and A...

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Autores principales: Lu, Xi-Lin, Xu, Zhong-Liang, Yao, Xiao-Li, Su, Feng-Juan, Ye, Cheng-Hui, Li, Jing, Lin, Yong-Cheng, Wang, Guang-Lei, Zeng, Jin-Sheng, Huang, Ru-Xun, Ou, Jing-Song, Sun, Hong-Shuo, Wang, Li-Ping, Pang, Ji-Yan, Pei, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397441/
https://www.ncbi.nlm.nih.gov/pubmed/22822374
http://dx.doi.org/10.3390/md10061307
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author Lu, Xi-Lin
Xu, Zhong-Liang
Yao, Xiao-Li
Su, Feng-Juan
Ye, Cheng-Hui
Li, Jing
Lin, Yong-Cheng
Wang, Guang-Lei
Zeng, Jin-Sheng
Huang, Ru-Xun
Ou, Jing-Song
Sun, Hong-Shuo
Wang, Li-Ping
Pang, Ji-Yan
Pei, Zhong
author_facet Lu, Xi-Lin
Xu, Zhong-Liang
Yao, Xiao-Li
Su, Feng-Juan
Ye, Cheng-Hui
Li, Jing
Lin, Yong-Cheng
Wang, Guang-Lei
Zeng, Jin-Sheng
Huang, Ru-Xun
Ou, Jing-Song
Sun, Hong-Shuo
Wang, Li-Ping
Pang, Ji-Yan
Pei, Zhong
author_sort Lu, Xi-Lin
collection PubMed
description Cyclotripeptide X-13 is a core of novel marine compound xyloallenoide A isolated from mangrove fungus Xylaria sp. (no. 2508). We found that X-13 dose-dependently induced angiogenesis in zebrafish embryos and in human endothelial cells, which was accompanied by increased phosphorylation of eNOS and Akt and NO release. Inhibition of PI3K/Akt/eNOS by LY294002 or L-NAME suppressed X-13-induced angiogenesis. The present work demonstrates that X-13 promotes angiogenesis via PI3K/Akt/eNOS pathways.
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spelling pubmed-33974412012-07-20 Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways Lu, Xi-Lin Xu, Zhong-Liang Yao, Xiao-Li Su, Feng-Juan Ye, Cheng-Hui Li, Jing Lin, Yong-Cheng Wang, Guang-Lei Zeng, Jin-Sheng Huang, Ru-Xun Ou, Jing-Song Sun, Hong-Shuo Wang, Li-Ping Pang, Ji-Yan Pei, Zhong Mar Drugs Article Cyclotripeptide X-13 is a core of novel marine compound xyloallenoide A isolated from mangrove fungus Xylaria sp. (no. 2508). We found that X-13 dose-dependently induced angiogenesis in zebrafish embryos and in human endothelial cells, which was accompanied by increased phosphorylation of eNOS and Akt and NO release. Inhibition of PI3K/Akt/eNOS by LY294002 or L-NAME suppressed X-13-induced angiogenesis. The present work demonstrates that X-13 promotes angiogenesis via PI3K/Akt/eNOS pathways. MDPI 2012-06-07 /pmc/articles/PMC3397441/ /pubmed/22822374 http://dx.doi.org/10.3390/md10061307 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Lu, Xi-Lin
Xu, Zhong-Liang
Yao, Xiao-Li
Su, Feng-Juan
Ye, Cheng-Hui
Li, Jing
Lin, Yong-Cheng
Wang, Guang-Lei
Zeng, Jin-Sheng
Huang, Ru-Xun
Ou, Jing-Song
Sun, Hong-Shuo
Wang, Li-Ping
Pang, Ji-Yan
Pei, Zhong
Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways
title Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways
title_full Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways
title_fullStr Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways
title_full_unstemmed Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways
title_short Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways
title_sort marine cyclotripeptide x-13 promotes angiogenesis in zebrafish and human endothelial cells via pi3k/akt/enos signaling pathways
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397441/
https://www.ncbi.nlm.nih.gov/pubmed/22822374
http://dx.doi.org/10.3390/md10061307
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