New Briarane Diterpenoids from the Gorgonian Coral Junceella juncea

Chemical investigation of Junceella juncea has resulted in the isolation of three new briaranes designated juncenolides M–O (1–3). The structures of these compounds were determined by spectroscopic analysis including 2D-NMR (COSY, HMBC and NOESY) and HRMS. Compound 1 is a new chlorinated briarane wh...

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Autores principales: Chang, Jiun-Yang, Liaw, Chia-Ching, Fazary, Ahmed Eid, Hwang, Tsong-Long, Shen, Ya-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397442/
https://www.ncbi.nlm.nih.gov/pubmed/22822375
http://dx.doi.org/10.3390/md10061321
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author Chang, Jiun-Yang
Liaw, Chia-Ching
Fazary, Ahmed Eid
Hwang, Tsong-Long
Shen, Ya-Ching
author_facet Chang, Jiun-Yang
Liaw, Chia-Ching
Fazary, Ahmed Eid
Hwang, Tsong-Long
Shen, Ya-Ching
author_sort Chang, Jiun-Yang
collection PubMed
description Chemical investigation of Junceella juncea has resulted in the isolation of three new briaranes designated juncenolides M–O (1–3). The structures of these compounds were determined by spectroscopic analysis including 2D-NMR (COSY, HMBC and NOESY) and HRMS. Compound 1 is a new chlorinated briarane while compound 3 contains a rare methyl ester at C-16. The anti-inflammatory activities tested on superoxide anion generation and elastase release by human neutrophils in response to FMLP/CB were evaluated.
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spelling pubmed-33974422012-07-20 New Briarane Diterpenoids from the Gorgonian Coral Junceella juncea Chang, Jiun-Yang Liaw, Chia-Ching Fazary, Ahmed Eid Hwang, Tsong-Long Shen, Ya-Ching Mar Drugs Article Chemical investigation of Junceella juncea has resulted in the isolation of three new briaranes designated juncenolides M–O (1–3). The structures of these compounds were determined by spectroscopic analysis including 2D-NMR (COSY, HMBC and NOESY) and HRMS. Compound 1 is a new chlorinated briarane while compound 3 contains a rare methyl ester at C-16. The anti-inflammatory activities tested on superoxide anion generation and elastase release by human neutrophils in response to FMLP/CB were evaluated. MDPI 2012-06-07 /pmc/articles/PMC3397442/ /pubmed/22822375 http://dx.doi.org/10.3390/md10061321 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Chang, Jiun-Yang
Liaw, Chia-Ching
Fazary, Ahmed Eid
Hwang, Tsong-Long
Shen, Ya-Ching
New Briarane Diterpenoids from the Gorgonian Coral Junceella juncea
title New Briarane Diterpenoids from the Gorgonian Coral Junceella juncea
title_full New Briarane Diterpenoids from the Gorgonian Coral Junceella juncea
title_fullStr New Briarane Diterpenoids from the Gorgonian Coral Junceella juncea
title_full_unstemmed New Briarane Diterpenoids from the Gorgonian Coral Junceella juncea
title_short New Briarane Diterpenoids from the Gorgonian Coral Junceella juncea
title_sort new briarane diterpenoids from the gorgonian coral junceella juncea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397442/
https://www.ncbi.nlm.nih.gov/pubmed/22822375
http://dx.doi.org/10.3390/md10061321
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