Chalinulasterol, a Chlorinated Steroid Disulfate from the Caribbean Sponge Chalinula molitba. Evaluation of Its Role as PXR Receptor Modulator

Chalinulasterol (1) a new chlorinated sterol disulfate was isolated from the Caribbean sponge Chalinula molitba. Its structure was elucidated using mass spectrometry and NMR experiments. The possible role of chalinulasterol as modulator of the PXR nuclear receptor was investigated but, in spite of t...

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Detalles Bibliográficos
Autores principales: Teta, Roberta, Sala, Gerardo Della, Renga, Barbara, Mangoni, Alfonso, Fiorucci, Stefano, Costantino, Valeria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397446/
https://www.ncbi.nlm.nih.gov/pubmed/22822379
http://dx.doi.org/10.3390/md10061383
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author Teta, Roberta
Sala, Gerardo Della
Renga, Barbara
Mangoni, Alfonso
Fiorucci, Stefano
Costantino, Valeria
author_facet Teta, Roberta
Sala, Gerardo Della
Renga, Barbara
Mangoni, Alfonso
Fiorucci, Stefano
Costantino, Valeria
author_sort Teta, Roberta
collection PubMed
description Chalinulasterol (1) a new chlorinated sterol disulfate was isolated from the Caribbean sponge Chalinula molitba. Its structure was elucidated using mass spectrometry and NMR experiments. The possible role of chalinulasterol as modulator of the PXR nuclear receptor was investigated but, in spite of the close structural relationship with the PXR agonist solomonsterol A (2), it showed no activity. The structural requirements for the PXR nuclear receptor activity were discussed.
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spelling pubmed-33974462012-07-20 Chalinulasterol, a Chlorinated Steroid Disulfate from the Caribbean Sponge Chalinula molitba. Evaluation of Its Role as PXR Receptor Modulator Teta, Roberta Sala, Gerardo Della Renga, Barbara Mangoni, Alfonso Fiorucci, Stefano Costantino, Valeria Mar Drugs Article Chalinulasterol (1) a new chlorinated sterol disulfate was isolated from the Caribbean sponge Chalinula molitba. Its structure was elucidated using mass spectrometry and NMR experiments. The possible role of chalinulasterol as modulator of the PXR nuclear receptor was investigated but, in spite of the close structural relationship with the PXR agonist solomonsterol A (2), it showed no activity. The structural requirements for the PXR nuclear receptor activity were discussed. MDPI 2012-06-14 /pmc/articles/PMC3397446/ /pubmed/22822379 http://dx.doi.org/10.3390/md10061383 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Teta, Roberta
Sala, Gerardo Della
Renga, Barbara
Mangoni, Alfonso
Fiorucci, Stefano
Costantino, Valeria
Chalinulasterol, a Chlorinated Steroid Disulfate from the Caribbean Sponge Chalinula molitba. Evaluation of Its Role as PXR Receptor Modulator
title Chalinulasterol, a Chlorinated Steroid Disulfate from the Caribbean Sponge Chalinula molitba. Evaluation of Its Role as PXR Receptor Modulator
title_full Chalinulasterol, a Chlorinated Steroid Disulfate from the Caribbean Sponge Chalinula molitba. Evaluation of Its Role as PXR Receptor Modulator
title_fullStr Chalinulasterol, a Chlorinated Steroid Disulfate from the Caribbean Sponge Chalinula molitba. Evaluation of Its Role as PXR Receptor Modulator
title_full_unstemmed Chalinulasterol, a Chlorinated Steroid Disulfate from the Caribbean Sponge Chalinula molitba. Evaluation of Its Role as PXR Receptor Modulator
title_short Chalinulasterol, a Chlorinated Steroid Disulfate from the Caribbean Sponge Chalinula molitba. Evaluation of Its Role as PXR Receptor Modulator
title_sort chalinulasterol, a chlorinated steroid disulfate from the caribbean sponge chalinula molitba. evaluation of its role as pxr receptor modulator
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397446/
https://www.ncbi.nlm.nih.gov/pubmed/22822379
http://dx.doi.org/10.3390/md10061383
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