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Pullularins E and F, Two New Peptides from the Endophytic Fungus Bionectria ochroleuca Isolated from the Mangrove Plant Sonneratia caseolaris
Chemical investigation of the EtOAc extract of the endophytic fungus Bionectria ochroleuca, isolated from the inner leaf tissues of the plant Sonneratia caseolaris (Sonneratiaceae) from Hainan island (China), yielded two new peptides, pullularins E and F (1 and 2) together with three known compounds...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397455/ https://www.ncbi.nlm.nih.gov/pubmed/22822358 http://dx.doi.org/10.3390/md10051081 |
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author | Ebrahim, Weaam Kjer, Julia El Amrani, Mustapha Wray, Victor Lin, Wenhan Ebel, Rainer Lai, Daowan Proksch, Peter |
author_facet | Ebrahim, Weaam Kjer, Julia El Amrani, Mustapha Wray, Victor Lin, Wenhan Ebel, Rainer Lai, Daowan Proksch, Peter |
author_sort | Ebrahim, Weaam |
collection | PubMed |
description | Chemical investigation of the EtOAc extract of the endophytic fungus Bionectria ochroleuca, isolated from the inner leaf tissues of the plant Sonneratia caseolaris (Sonneratiaceae) from Hainan island (China), yielded two new peptides, pullularins E and F (1 and 2) together with three known compounds (3–5). The structures of the new compounds were unambiguously determined on the basis of one- and two-dimensional NMR spectroscopy as well as by high-resolution mass spectrometry. The absolute configurations of amino acids were determined by HPLC analysis of acid hydrolysates using Marfey’s method. The isolated compounds exhibited pronounced to moderate cytotoxic activity against the mouse lymphoma cells (L5178Y) with EC(50) values ranging between 0.1 and 6.7 µg/mL. |
format | Online Article Text |
id | pubmed-3397455 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-33974552012-07-20 Pullularins E and F, Two New Peptides from the Endophytic Fungus Bionectria ochroleuca Isolated from the Mangrove Plant Sonneratia caseolaris Ebrahim, Weaam Kjer, Julia El Amrani, Mustapha Wray, Victor Lin, Wenhan Ebel, Rainer Lai, Daowan Proksch, Peter Mar Drugs Article Chemical investigation of the EtOAc extract of the endophytic fungus Bionectria ochroleuca, isolated from the inner leaf tissues of the plant Sonneratia caseolaris (Sonneratiaceae) from Hainan island (China), yielded two new peptides, pullularins E and F (1 and 2) together with three known compounds (3–5). The structures of the new compounds were unambiguously determined on the basis of one- and two-dimensional NMR spectroscopy as well as by high-resolution mass spectrometry. The absolute configurations of amino acids were determined by HPLC analysis of acid hydrolysates using Marfey’s method. The isolated compounds exhibited pronounced to moderate cytotoxic activity against the mouse lymphoma cells (L5178Y) with EC(50) values ranging between 0.1 and 6.7 µg/mL. MDPI 2012-05-18 /pmc/articles/PMC3397455/ /pubmed/22822358 http://dx.doi.org/10.3390/md10051081 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Ebrahim, Weaam Kjer, Julia El Amrani, Mustapha Wray, Victor Lin, Wenhan Ebel, Rainer Lai, Daowan Proksch, Peter Pullularins E and F, Two New Peptides from the Endophytic Fungus Bionectria ochroleuca Isolated from the Mangrove Plant Sonneratia caseolaris |
title | Pullularins E and F, Two New Peptides from the Endophytic Fungus Bionectria ochroleuca Isolated from the Mangrove Plant Sonneratia caseolaris |
title_full | Pullularins E and F, Two New Peptides from the Endophytic Fungus Bionectria ochroleuca Isolated from the Mangrove Plant Sonneratia caseolaris |
title_fullStr | Pullularins E and F, Two New Peptides from the Endophytic Fungus Bionectria ochroleuca Isolated from the Mangrove Plant Sonneratia caseolaris |
title_full_unstemmed | Pullularins E and F, Two New Peptides from the Endophytic Fungus Bionectria ochroleuca Isolated from the Mangrove Plant Sonneratia caseolaris |
title_short | Pullularins E and F, Two New Peptides from the Endophytic Fungus Bionectria ochroleuca Isolated from the Mangrove Plant Sonneratia caseolaris |
title_sort | pullularins e and f, two new peptides from the endophytic fungus bionectria ochroleuca isolated from the mangrove plant sonneratia caseolaris |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397455/ https://www.ncbi.nlm.nih.gov/pubmed/22822358 http://dx.doi.org/10.3390/md10051081 |
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