Briacavatolides A–C, New Briaranes from the Taiwanese Octocoral Briareum excavatum

In order to search for novel bioactive substances from marine organisms, we have investigated the organic extracts of the Taiwanese octocoral Briareum excavatum collected at Orchid Island. Three new briarane-type diterpenoids, briacavatolides A–C (1–3) as well as two known briaranes, briaexcavatolid...

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Autores principales: Yeh, Tsun-Tai, Wang, Shang-Kwei, Dai, Chang-Feng, Duh, Chang-Yih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397463/
https://www.ncbi.nlm.nih.gov/pubmed/22822353
http://dx.doi.org/10.3390/md10051019
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author Yeh, Tsun-Tai
Wang, Shang-Kwei
Dai, Chang-Feng
Duh, Chang-Yih
author_facet Yeh, Tsun-Tai
Wang, Shang-Kwei
Dai, Chang-Feng
Duh, Chang-Yih
author_sort Yeh, Tsun-Tai
collection PubMed
description In order to search for novel bioactive substances from marine organisms, we have investigated the organic extracts of the Taiwanese octocoral Briareum excavatum collected at Orchid Island. Three new briarane-type diterpenoids, briacavatolides A–C (1–3) as well as two known briaranes, briaexcavatolide U (4) and briaexcavatin L (5) were isolated from the acetone extract. The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV (human cytomegalovirus) activity of 1–5 and their cytotoxicity against selected cancer cell lines were evaluated.
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spelling pubmed-33974632012-07-20 Briacavatolides A–C, New Briaranes from the Taiwanese Octocoral Briareum excavatum Yeh, Tsun-Tai Wang, Shang-Kwei Dai, Chang-Feng Duh, Chang-Yih Mar Drugs Article In order to search for novel bioactive substances from marine organisms, we have investigated the organic extracts of the Taiwanese octocoral Briareum excavatum collected at Orchid Island. Three new briarane-type diterpenoids, briacavatolides A–C (1–3) as well as two known briaranes, briaexcavatolide U (4) and briaexcavatin L (5) were isolated from the acetone extract. The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV (human cytomegalovirus) activity of 1–5 and their cytotoxicity against selected cancer cell lines were evaluated. MDPI 2012-05-02 /pmc/articles/PMC3397463/ /pubmed/22822353 http://dx.doi.org/10.3390/md10051019 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Yeh, Tsun-Tai
Wang, Shang-Kwei
Dai, Chang-Feng
Duh, Chang-Yih
Briacavatolides A–C, New Briaranes from the Taiwanese Octocoral Briareum excavatum
title Briacavatolides A–C, New Briaranes from the Taiwanese Octocoral Briareum excavatum
title_full Briacavatolides A–C, New Briaranes from the Taiwanese Octocoral Briareum excavatum
title_fullStr Briacavatolides A–C, New Briaranes from the Taiwanese Octocoral Briareum excavatum
title_full_unstemmed Briacavatolides A–C, New Briaranes from the Taiwanese Octocoral Briareum excavatum
title_short Briacavatolides A–C, New Briaranes from the Taiwanese Octocoral Briareum excavatum
title_sort briacavatolides a–c, new briaranes from the taiwanese octocoral briareum excavatum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397463/
https://www.ncbi.nlm.nih.gov/pubmed/22822353
http://dx.doi.org/10.3390/md10051019
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