Structure Elucidation and Anticancer Activity of 7-Oxostaurosporine Derivatives from the Brazilian Endemic Tunicate Eudistoma vannamei

The present study reports the identification of two new staurosporine derivatives, 2-hydroxy-7-oxostaurosporine (1) and 3-hydroxy-7-oxostaurosporine (2), obtained from mid-polar fractions of an aqueous methanol extract of the tunicate Eudistoma vannamei, endemic to the northeast coast of Brazil. The...

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Autores principales: Jimenez, Paula Christine, Wilke, Diego Veras, Ferreira, Elthon Gois, Takeara, Renata, de Moraes, Manoel Odorico, da Silveira, Edilberto Rocha, da Cruz Lotufo, Tito Monteiro, Lopes, Norberto Peporine, Costa-Lotufo, Leticia Veras
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397465/
https://www.ncbi.nlm.nih.gov/pubmed/22822359
http://dx.doi.org/10.3390/md10051092
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author Jimenez, Paula Christine
Wilke, Diego Veras
Ferreira, Elthon Gois
Takeara, Renata
de Moraes, Manoel Odorico
da Silveira, Edilberto Rocha
da Cruz Lotufo, Tito Monteiro
Lopes, Norberto Peporine
Costa-Lotufo, Leticia Veras
author_facet Jimenez, Paula Christine
Wilke, Diego Veras
Ferreira, Elthon Gois
Takeara, Renata
de Moraes, Manoel Odorico
da Silveira, Edilberto Rocha
da Cruz Lotufo, Tito Monteiro
Lopes, Norberto Peporine
Costa-Lotufo, Leticia Veras
author_sort Jimenez, Paula Christine
collection PubMed
description The present study reports the identification of two new staurosporine derivatives, 2-hydroxy-7-oxostaurosporine (1) and 3-hydroxy-7-oxostaurosporine (2), obtained from mid-polar fractions of an aqueous methanol extract of the tunicate Eudistoma vannamei, endemic to the northeast coast of Brazil. The mixture of 1 and 2 displayed IC(50) values in the nM range and was up to 14 times more cytotoxic than staurosporine across a panel of tumor cell lines, as evaluated using the MTT assay.
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spelling pubmed-33974652012-07-20 Structure Elucidation and Anticancer Activity of 7-Oxostaurosporine Derivatives from the Brazilian Endemic Tunicate Eudistoma vannamei Jimenez, Paula Christine Wilke, Diego Veras Ferreira, Elthon Gois Takeara, Renata de Moraes, Manoel Odorico da Silveira, Edilberto Rocha da Cruz Lotufo, Tito Monteiro Lopes, Norberto Peporine Costa-Lotufo, Leticia Veras Mar Drugs Article The present study reports the identification of two new staurosporine derivatives, 2-hydroxy-7-oxostaurosporine (1) and 3-hydroxy-7-oxostaurosporine (2), obtained from mid-polar fractions of an aqueous methanol extract of the tunicate Eudistoma vannamei, endemic to the northeast coast of Brazil. The mixture of 1 and 2 displayed IC(50) values in the nM range and was up to 14 times more cytotoxic than staurosporine across a panel of tumor cell lines, as evaluated using the MTT assay. MDPI 2012-05-21 /pmc/articles/PMC3397465/ /pubmed/22822359 http://dx.doi.org/10.3390/md10051092 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Jimenez, Paula Christine
Wilke, Diego Veras
Ferreira, Elthon Gois
Takeara, Renata
de Moraes, Manoel Odorico
da Silveira, Edilberto Rocha
da Cruz Lotufo, Tito Monteiro
Lopes, Norberto Peporine
Costa-Lotufo, Leticia Veras
Structure Elucidation and Anticancer Activity of 7-Oxostaurosporine Derivatives from the Brazilian Endemic Tunicate Eudistoma vannamei
title Structure Elucidation and Anticancer Activity of 7-Oxostaurosporine Derivatives from the Brazilian Endemic Tunicate Eudistoma vannamei
title_full Structure Elucidation and Anticancer Activity of 7-Oxostaurosporine Derivatives from the Brazilian Endemic Tunicate Eudistoma vannamei
title_fullStr Structure Elucidation and Anticancer Activity of 7-Oxostaurosporine Derivatives from the Brazilian Endemic Tunicate Eudistoma vannamei
title_full_unstemmed Structure Elucidation and Anticancer Activity of 7-Oxostaurosporine Derivatives from the Brazilian Endemic Tunicate Eudistoma vannamei
title_short Structure Elucidation and Anticancer Activity of 7-Oxostaurosporine Derivatives from the Brazilian Endemic Tunicate Eudistoma vannamei
title_sort structure elucidation and anticancer activity of 7-oxostaurosporine derivatives from the brazilian endemic tunicate eudistoma vannamei
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397465/
https://www.ncbi.nlm.nih.gov/pubmed/22822359
http://dx.doi.org/10.3390/md10051092
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