A Novel Chemometric Method for the Prediction of Human Oral Bioavailability

Orally administered drugs must overcome several barriers before reaching their target site. Such barriers depend largely upon specific membrane transport systems and intracellular drug-metabolizing enzymes. For the first time, the P-glycoprotein (P-gp) and cytochrome P450s, the main line of defense...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Xue, Zhang, Wuxia, Huang, Chao, Li, Yan, Yu, Hua, Wang, Yonghua, Duan, Jinyou, Ling, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397506/
https://www.ncbi.nlm.nih.gov/pubmed/22837674
http://dx.doi.org/10.3390/ijms13066964

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397506/
https://www.ncbi.nlm.nih.gov/pubmed/22837674
http://dx.doi.org/10.3390/ijms13066964

Ejemplares similares