Target Molecular Simulations of RecA Family Protein Filaments

Modeling of the RadA family mechanism is crucial to understanding the DNA SOS repair process. In a 2007 report, the archaeal RadA proteins function as rotary motors (linker region: I71-K88) such as shown in Figure 1. Molecular simulations approaches help to shed further light onto this phenomenon. W...

Descripción completa

Detalles Bibliográficos
Autores principales: Su, Zhi-Yuan, Lee, Wen-Jay, Su, Wan-Sheng, Wang, Yeng-Tseng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397515/
https://www.ncbi.nlm.nih.gov/pubmed/22837683
http://dx.doi.org/10.3390/ijms13067138
_version_ 1782238196092895232
author Su, Zhi-Yuan
Lee, Wen-Jay
Su, Wan-Sheng
Wang, Yeng-Tseng
author_facet Su, Zhi-Yuan
Lee, Wen-Jay
Su, Wan-Sheng
Wang, Yeng-Tseng
author_sort Su, Zhi-Yuan
collection PubMed
description Modeling of the RadA family mechanism is crucial to understanding the DNA SOS repair process. In a 2007 report, the archaeal RadA proteins function as rotary motors (linker region: I71-K88) such as shown in Figure 1. Molecular simulations approaches help to shed further light onto this phenomenon. We find 11 rotary residues (R72, T75-K81, M84, V86 and K87) and five zero rotary residues (I71, K74, E82, R83 and K88) in the simulations. Inclusion of our simulations may help to understand the RadA family mechanism.
format Online
Article
Text
id pubmed-3397515
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Molecular Diversity Preservation International (MDPI)
record_format MEDLINE/PubMed
spelling pubmed-33975152012-07-26 Target Molecular Simulations of RecA Family Protein Filaments Su, Zhi-Yuan Lee, Wen-Jay Su, Wan-Sheng Wang, Yeng-Tseng Int J Mol Sci Communication Modeling of the RadA family mechanism is crucial to understanding the DNA SOS repair process. In a 2007 report, the archaeal RadA proteins function as rotary motors (linker region: I71-K88) such as shown in Figure 1. Molecular simulations approaches help to shed further light onto this phenomenon. We find 11 rotary residues (R72, T75-K81, M84, V86 and K87) and five zero rotary residues (I71, K74, E82, R83 and K88) in the simulations. Inclusion of our simulations may help to understand the RadA family mechanism. Molecular Diversity Preservation International (MDPI) 2012-06-11 /pmc/articles/PMC3397515/ /pubmed/22837683 http://dx.doi.org/10.3390/ijms13067138 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Su, Zhi-Yuan
Lee, Wen-Jay
Su, Wan-Sheng
Wang, Yeng-Tseng
Target Molecular Simulations of RecA Family Protein Filaments
title Target Molecular Simulations of RecA Family Protein Filaments
title_full Target Molecular Simulations of RecA Family Protein Filaments
title_fullStr Target Molecular Simulations of RecA Family Protein Filaments
title_full_unstemmed Target Molecular Simulations of RecA Family Protein Filaments
title_short Target Molecular Simulations of RecA Family Protein Filaments
title_sort target molecular simulations of reca family protein filaments
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397515/
https://www.ncbi.nlm.nih.gov/pubmed/22837683
http://dx.doi.org/10.3390/ijms13067138
work_keys_str_mv AT suzhiyuan targetmolecularsimulationsofrecafamilyproteinfilaments
AT leewenjay targetmolecularsimulationsofrecafamilyproteinfilaments
AT suwansheng targetmolecularsimulationsofrecafamilyproteinfilaments
AT wangyengtseng targetmolecularsimulationsofrecafamilyproteinfilaments

Ejemplares similares