Cargando…

Biodegradation Study of Microcrystalline Chitosan and Microcrystalline Chitosan/β-TCP Complex Composites

Bone repair or regeneration is a common and complicated clinical problem in orthopedic surgery. The importance of natural polymers, such as microcrystalline chitosan, and minerals such as HAp and β-TCP, has grown significantly over the last two decades due to their renewable and biodegradable source...

Descripción completa

Detalles Bibliográficos
Autores principales: Pighinelli, Luciano, Kucharska, Magdalena, Wísniewska-Wrona, Maria, Gruchała, Bogdan, Brzoza-Malczewska, Kinga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397549/
https://www.ncbi.nlm.nih.gov/pubmed/22837717
http://dx.doi.org/10.3390/ijms13067617
_version_ 1782238203914223616
author Pighinelli, Luciano
Kucharska, Magdalena
Wísniewska-Wrona, Maria
Gruchała, Bogdan
Brzoza-Malczewska, Kinga
author_facet Pighinelli, Luciano
Kucharska, Magdalena
Wísniewska-Wrona, Maria
Gruchała, Bogdan
Brzoza-Malczewska, Kinga
author_sort Pighinelli, Luciano
collection PubMed
description Bone repair or regeneration is a common and complicated clinical problem in orthopedic surgery. The importance of natural polymers, such as microcrystalline chitosan, and minerals such as HAp and β-TCP, has grown significantly over the last two decades due to their renewable and biodegradable source, increasing the knowledge and functionality of composites in technological and biomedical applications. This study compares the biodegradation process, bioactivity, structure, morphology, and mechanical properties of microcrystalline chitosan and microcrystalline chitosan/β-TCP complex; the latter according to the new method of preparation. The complex showed a homogeneous network structure with regular pores, good bioactivity, even after 60 days of conducting the hydrolytic and enzymatic degradation process, showing a bacteriostatic and bactericidal activity. The complex indicates that it could be used successfully as a base for implants and scaffolds production in orthopedic surgery.
format Online
Article
Text
id pubmed-3397549
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Molecular Diversity Preservation International (MDPI)
record_format MEDLINE/PubMed
spelling pubmed-33975492012-07-26 Biodegradation Study of Microcrystalline Chitosan and Microcrystalline Chitosan/β-TCP Complex Composites Pighinelli, Luciano Kucharska, Magdalena Wísniewska-Wrona, Maria Gruchała, Bogdan Brzoza-Malczewska, Kinga Int J Mol Sci Article Bone repair or regeneration is a common and complicated clinical problem in orthopedic surgery. The importance of natural polymers, such as microcrystalline chitosan, and minerals such as HAp and β-TCP, has grown significantly over the last two decades due to their renewable and biodegradable source, increasing the knowledge and functionality of composites in technological and biomedical applications. This study compares the biodegradation process, bioactivity, structure, morphology, and mechanical properties of microcrystalline chitosan and microcrystalline chitosan/β-TCP complex; the latter according to the new method of preparation. The complex showed a homogeneous network structure with regular pores, good bioactivity, even after 60 days of conducting the hydrolytic and enzymatic degradation process, showing a bacteriostatic and bactericidal activity. The complex indicates that it could be used successfully as a base for implants and scaffolds production in orthopedic surgery. Molecular Diversity Preservation International (MDPI) 2012-06-21 /pmc/articles/PMC3397549/ /pubmed/22837717 http://dx.doi.org/10.3390/ijms13067617 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Pighinelli, Luciano
Kucharska, Magdalena
Wísniewska-Wrona, Maria
Gruchała, Bogdan
Brzoza-Malczewska, Kinga
Biodegradation Study of Microcrystalline Chitosan and Microcrystalline Chitosan/β-TCP Complex Composites
title Biodegradation Study of Microcrystalline Chitosan and Microcrystalline Chitosan/β-TCP Complex Composites
title_full Biodegradation Study of Microcrystalline Chitosan and Microcrystalline Chitosan/β-TCP Complex Composites
title_fullStr Biodegradation Study of Microcrystalline Chitosan and Microcrystalline Chitosan/β-TCP Complex Composites
title_full_unstemmed Biodegradation Study of Microcrystalline Chitosan and Microcrystalline Chitosan/β-TCP Complex Composites
title_short Biodegradation Study of Microcrystalline Chitosan and Microcrystalline Chitosan/β-TCP Complex Composites
title_sort biodegradation study of microcrystalline chitosan and microcrystalline chitosan/β-tcp complex composites
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397549/
https://www.ncbi.nlm.nih.gov/pubmed/22837717
http://dx.doi.org/10.3390/ijms13067617
work_keys_str_mv AT pighinelliluciano biodegradationstudyofmicrocrystallinechitosanandmicrocrystallinechitosanbtcpcomplexcomposites
AT kucharskamagdalena biodegradationstudyofmicrocrystallinechitosanandmicrocrystallinechitosanbtcpcomplexcomposites
AT wisniewskawronamaria biodegradationstudyofmicrocrystallinechitosanandmicrocrystallinechitosanbtcpcomplexcomposites
AT gruchałabogdan biodegradationstudyofmicrocrystallinechitosanandmicrocrystallinechitosanbtcpcomplexcomposites
AT brzozamalczewskakinga biodegradationstudyofmicrocrystallinechitosanandmicrocrystallinechitosanbtcpcomplexcomposites