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Biodegradation Study of Microcrystalline Chitosan and Microcrystalline Chitosan/β-TCP Complex Composites
Bone repair or regeneration is a common and complicated clinical problem in orthopedic surgery. The importance of natural polymers, such as microcrystalline chitosan, and minerals such as HAp and β-TCP, has grown significantly over the last two decades due to their renewable and biodegradable source...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397549/ https://www.ncbi.nlm.nih.gov/pubmed/22837717 http://dx.doi.org/10.3390/ijms13067617 |
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author | Pighinelli, Luciano Kucharska, Magdalena Wísniewska-Wrona, Maria Gruchała, Bogdan Brzoza-Malczewska, Kinga |
author_facet | Pighinelli, Luciano Kucharska, Magdalena Wísniewska-Wrona, Maria Gruchała, Bogdan Brzoza-Malczewska, Kinga |
author_sort | Pighinelli, Luciano |
collection | PubMed |
description | Bone repair or regeneration is a common and complicated clinical problem in orthopedic surgery. The importance of natural polymers, such as microcrystalline chitosan, and minerals such as HAp and β-TCP, has grown significantly over the last two decades due to their renewable and biodegradable source, increasing the knowledge and functionality of composites in technological and biomedical applications. This study compares the biodegradation process, bioactivity, structure, morphology, and mechanical properties of microcrystalline chitosan and microcrystalline chitosan/β-TCP complex; the latter according to the new method of preparation. The complex showed a homogeneous network structure with regular pores, good bioactivity, even after 60 days of conducting the hydrolytic and enzymatic degradation process, showing a bacteriostatic and bactericidal activity. The complex indicates that it could be used successfully as a base for implants and scaffolds production in orthopedic surgery. |
format | Online Article Text |
id | pubmed-3397549 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-33975492012-07-26 Biodegradation Study of Microcrystalline Chitosan and Microcrystalline Chitosan/β-TCP Complex Composites Pighinelli, Luciano Kucharska, Magdalena Wísniewska-Wrona, Maria Gruchała, Bogdan Brzoza-Malczewska, Kinga Int J Mol Sci Article Bone repair or regeneration is a common and complicated clinical problem in orthopedic surgery. The importance of natural polymers, such as microcrystalline chitosan, and minerals such as HAp and β-TCP, has grown significantly over the last two decades due to their renewable and biodegradable source, increasing the knowledge and functionality of composites in technological and biomedical applications. This study compares the biodegradation process, bioactivity, structure, morphology, and mechanical properties of microcrystalline chitosan and microcrystalline chitosan/β-TCP complex; the latter according to the new method of preparation. The complex showed a homogeneous network structure with regular pores, good bioactivity, even after 60 days of conducting the hydrolytic and enzymatic degradation process, showing a bacteriostatic and bactericidal activity. The complex indicates that it could be used successfully as a base for implants and scaffolds production in orthopedic surgery. Molecular Diversity Preservation International (MDPI) 2012-06-21 /pmc/articles/PMC3397549/ /pubmed/22837717 http://dx.doi.org/10.3390/ijms13067617 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Pighinelli, Luciano Kucharska, Magdalena Wísniewska-Wrona, Maria Gruchała, Bogdan Brzoza-Malczewska, Kinga Biodegradation Study of Microcrystalline Chitosan and Microcrystalline Chitosan/β-TCP Complex Composites |
title | Biodegradation Study of Microcrystalline Chitosan and Microcrystalline Chitosan/β-TCP Complex Composites |
title_full | Biodegradation Study of Microcrystalline Chitosan and Microcrystalline Chitosan/β-TCP Complex Composites |
title_fullStr | Biodegradation Study of Microcrystalline Chitosan and Microcrystalline Chitosan/β-TCP Complex Composites |
title_full_unstemmed | Biodegradation Study of Microcrystalline Chitosan and Microcrystalline Chitosan/β-TCP Complex Composites |
title_short | Biodegradation Study of Microcrystalline Chitosan and Microcrystalline Chitosan/β-TCP Complex Composites |
title_sort | biodegradation study of microcrystalline chitosan and microcrystalline chitosan/β-tcp complex composites |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397549/ https://www.ncbi.nlm.nih.gov/pubmed/22837717 http://dx.doi.org/10.3390/ijms13067617 |
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