Clinical Neuroprotective Drugs for Treatment and Prevention of Stroke

Stroke is an enormous public health problem with an imperative need for more effective therapies. In therapies for ischemic stroke, tissue plasminogen activators, antiplatelet agents and anticoagulants are used mainly for their antithrombotic effects. However, free radical scavengers, minocycline an...

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Detalles Bibliográficos
Autores principales: Kikuchi, Kiyoshi, Uchikado, Hisaaki, Morioka, Motohiro, Murai, Yoshinaka, Tanaka, Eiichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397556/
https://www.ncbi.nlm.nih.gov/pubmed/22837724
http://dx.doi.org/10.3390/ijms13067739
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author Kikuchi, Kiyoshi
Uchikado, Hisaaki
Morioka, Motohiro
Murai, Yoshinaka
Tanaka, Eiichiro
author_facet Kikuchi, Kiyoshi
Uchikado, Hisaaki
Morioka, Motohiro
Murai, Yoshinaka
Tanaka, Eiichiro
author_sort Kikuchi, Kiyoshi
collection PubMed
description Stroke is an enormous public health problem with an imperative need for more effective therapies. In therapies for ischemic stroke, tissue plasminogen activators, antiplatelet agents and anticoagulants are used mainly for their antithrombotic effects. However, free radical scavengers, minocycline and growth factors have shown neuroprotective effects in the treatment of stroke, while antihypertensive drugs, lipid-lowering drugs and hypoglycemic drugs have shown beneficial effects for the prevention of stroke. In the present review, we evaluate the treatment and prevention of stroke in light of clinical studies and discuss new anti-stroke effects other than the main effects of drugs, focusing on optimal pharmacotherapy.
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spelling pubmed-33975562012-07-26 Clinical Neuroprotective Drugs for Treatment and Prevention of Stroke Kikuchi, Kiyoshi Uchikado, Hisaaki Morioka, Motohiro Murai, Yoshinaka Tanaka, Eiichiro Int J Mol Sci Review Stroke is an enormous public health problem with an imperative need for more effective therapies. In therapies for ischemic stroke, tissue plasminogen activators, antiplatelet agents and anticoagulants are used mainly for their antithrombotic effects. However, free radical scavengers, minocycline and growth factors have shown neuroprotective effects in the treatment of stroke, while antihypertensive drugs, lipid-lowering drugs and hypoglycemic drugs have shown beneficial effects for the prevention of stroke. In the present review, we evaluate the treatment and prevention of stroke in light of clinical studies and discuss new anti-stroke effects other than the main effects of drugs, focusing on optimal pharmacotherapy. Molecular Diversity Preservation International (MDPI) 2012-06-21 /pmc/articles/PMC3397556/ /pubmed/22837724 http://dx.doi.org/10.3390/ijms13067739 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Kikuchi, Kiyoshi
Uchikado, Hisaaki
Morioka, Motohiro
Murai, Yoshinaka
Tanaka, Eiichiro
Clinical Neuroprotective Drugs for Treatment and Prevention of Stroke
title Clinical Neuroprotective Drugs for Treatment and Prevention of Stroke
title_full Clinical Neuroprotective Drugs for Treatment and Prevention of Stroke
title_fullStr Clinical Neuroprotective Drugs for Treatment and Prevention of Stroke
title_full_unstemmed Clinical Neuroprotective Drugs for Treatment and Prevention of Stroke
title_short Clinical Neuroprotective Drugs for Treatment and Prevention of Stroke
title_sort clinical neuroprotective drugs for treatment and prevention of stroke
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397556/
https://www.ncbi.nlm.nih.gov/pubmed/22837724
http://dx.doi.org/10.3390/ijms13067739
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