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Age-related variation in immunity in a wild mammal population
Age-related changes in immunity are well documented in humans and laboratory mammals. Using blood samples collected from wild Soay sheep, we show that pronounced differences in T-cell subsets and inflammatory markers amongst age classes are also evident under natural conditions. These shifts paralle...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397677/ https://www.ncbi.nlm.nih.gov/pubmed/22107028 http://dx.doi.org/10.1111/j.1474-9726.2011.00771.x |
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author | Nussey, Daniel H Watt, Kathryn Pilkington, Jill G Zamoyska, Rose McNeilly, Tom N |
author_facet | Nussey, Daniel H Watt, Kathryn Pilkington, Jill G Zamoyska, Rose McNeilly, Tom N |
author_sort | Nussey, Daniel H |
collection | PubMed |
description | Age-related changes in immunity are well documented in humans and laboratory mammals. Using blood samples collected from wild Soay sheep, we show that pronounced differences in T-cell subsets and inflammatory markers amongst age classes are also evident under natural conditions. These shifts parallel those observed in mammals experiencing protected environments. We found progressive declines in the proportion of naïve CD4 T cells with age, a precipitous drop in γδ T cells after the second year of life and an increase in acute phase protein levels amongst geriatric sheep. Our findings suggest immune aging patterns observed in laboratory and domestic mammals may generalize to more complex, challenging environments and could have fitness costs under natural conditions. |
format | Online Article Text |
id | pubmed-3397677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-33976772012-07-17 Age-related variation in immunity in a wild mammal population Nussey, Daniel H Watt, Kathryn Pilkington, Jill G Zamoyska, Rose McNeilly, Tom N Aging Cell Short Take Age-related changes in immunity are well documented in humans and laboratory mammals. Using blood samples collected from wild Soay sheep, we show that pronounced differences in T-cell subsets and inflammatory markers amongst age classes are also evident under natural conditions. These shifts parallel those observed in mammals experiencing protected environments. We found progressive declines in the proportion of naïve CD4 T cells with age, a precipitous drop in γδ T cells after the second year of life and an increase in acute phase protein levels amongst geriatric sheep. Our findings suggest immune aging patterns observed in laboratory and domestic mammals may generalize to more complex, challenging environments and could have fitness costs under natural conditions. Blackwell Publishing Ltd 2012-02 /pmc/articles/PMC3397677/ /pubmed/22107028 http://dx.doi.org/10.1111/j.1474-9726.2011.00771.x Text en © 2011 The Authors Aging Cell © 2011 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://wileyonlinelibrary.com/onlineopen#OnlineOpen_Terms |
spellingShingle | Short Take Nussey, Daniel H Watt, Kathryn Pilkington, Jill G Zamoyska, Rose McNeilly, Tom N Age-related variation in immunity in a wild mammal population |
title | Age-related variation in immunity in a wild mammal population |
title_full | Age-related variation in immunity in a wild mammal population |
title_fullStr | Age-related variation in immunity in a wild mammal population |
title_full_unstemmed | Age-related variation in immunity in a wild mammal population |
title_short | Age-related variation in immunity in a wild mammal population |
title_sort | age-related variation in immunity in a wild mammal population |
topic | Short Take |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397677/ https://www.ncbi.nlm.nih.gov/pubmed/22107028 http://dx.doi.org/10.1111/j.1474-9726.2011.00771.x |
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