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Significant Impact of Single N-Glycan Residues on the Biological Activity of Fc-based Antibody-like Fragments

Recent studies have demonstrated that IgG-Fc fragments (Fcabs) can be engineered to form antigen-binding sites with antibody properties. Thus they may serve as an attractive alternative to conventional antibodies in therapeutic applications. The critical influence of Fc glycosylation on effector fun...

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Detalles Bibliográficos
Autores principales:	Jez, Jakub, Antes, Bernhard, Castilho, Alexandra, Kainer, Manuela, Wiederkum, Susanne, Grass, Josephine, Rüker, Florian, Woisetschläger, Max, Steinkellner, Herta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	Glycobiology and Extracellular Matrices
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397857/ https://www.ncbi.nlm.nih.gov/pubmed/22589538 http://dx.doi.org/10.1074/jbc.M112.360701

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