Identification of Potential Small Molecule Binding Pockets on Rho Family GTPases

Rho GTPases are conformational switches that control a wide variety of signaling pathways critical for eukaryotic cell development and proliferation. They represent attractive targets for drug design as their aberrant function and deregulated activity is associated with many human diseases including...

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Detalles Bibliográficos
Autores principales: Ortiz-Sanchez, Juan Manuel, Nichols, Sara E., Sayyah, Jacqueline, Brown, Joan Heller, McCammon, J. Andrew, Grant, Barry J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397943/
https://www.ncbi.nlm.nih.gov/pubmed/22815826
http://dx.doi.org/10.1371/journal.pone.0040809

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397943/
https://www.ncbi.nlm.nih.gov/pubmed/22815826
http://dx.doi.org/10.1371/journal.pone.0040809

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