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Identification of Potential Small Molecule Binding Pockets on Rho Family GTPases
Rho GTPases are conformational switches that control a wide variety of signaling pathways critical for eukaryotic cell development and proliferation. They represent attractive targets for drug design as their aberrant function and deregulated activity is associated with many human diseases including...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397943/ https://www.ncbi.nlm.nih.gov/pubmed/22815826 http://dx.doi.org/10.1371/journal.pone.0040809 |