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The Role of Activity in Synaptic Degeneration in a Protein Misfolding Disease, Prion Disease

In chronic neurodegenerative diseases associated with aggregates of misfolded proteins (such as Alzheimer's, Parkinson's and prion disease), there is an early degeneration of presynaptic terminals prior to the loss of the neuronal somata. Identifying the mechanisms that govern synapse dege...

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Detalles Bibliográficos
Autores principales:	Caleo, Matteo, Restani, Laura, Vannini, Eleonora, Siskova, Zuzana, Al-Malki, Hussain, Morgan, Ruth, O'Connor, Vincent, Perry, V. Hugh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397974/ https://www.ncbi.nlm.nih.gov/pubmed/22815961 http://dx.doi.org/10.1371/journal.pone.0041182

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