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Synergistic Effect between Alcohol Consumption and Familial Susceptibility on Lung Cancer Risk among Chinese Men

We aimed to examine the effect of alcohol consumption on lung cancer risk stratified by smoking, and to explore whether the impact of alcohol was modified by familial susceptibility to cancer. We recruited 1208 male lung cancer incident cases and 1069 community referents during 2004–2006 and collect...

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Autores principales: Tse, Lap Ah, Yu, Ignatius Tak-sun, Wang, Xiao-rong, Qiu, Hong, Au, Joseph Siu Kie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398013/
https://www.ncbi.nlm.nih.gov/pubmed/22815780
http://dx.doi.org/10.1371/journal.pone.0040647
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author Tse, Lap Ah
Yu, Ignatius Tak-sun
Wang, Xiao-rong
Qiu, Hong
Au, Joseph Siu Kie
author_facet Tse, Lap Ah
Yu, Ignatius Tak-sun
Wang, Xiao-rong
Qiu, Hong
Au, Joseph Siu Kie
author_sort Tse, Lap Ah
collection PubMed
description We aimed to examine the effect of alcohol consumption on lung cancer risk stratified by smoking, and to explore whether the impact of alcohol was modified by familial susceptibility to cancer. We recruited 1208 male lung cancer incident cases and 1069 community referents during 2004–2006 and collected their lifetime history of alcohol consumption, cigarette smoking, and family cancer history. Unconditional multivariate logistic regression analysis was performed to estimate the adjusted odds ratio (OR). We tested multiplicative-scale interaction between exposures of interest and examined the additive-scale interaction using synergy index. A moderate association between frequent alcohol consumption and lung cancer was observed among men who had family cancer history (OR = 4.22, 95%CI: 2.46–7.23) after adjustment of smoking and other confounders, while the alcohol effect among men without family history was weak (OR = 1.24, 95%CI: 0.95–1.63) and it became no excess in the never smokers. We observed a consistent synergistic effect between alcohol drinking and family cancer history for all lung cancers and the adenocarcinoma, while there was no multiplicative-scale interaction between the exposures of interest (likelihood ratio test for interaction, p>0.05). Our study revealed a possible synergistic effect between alcohol consumption and familial susceptibility for lung cancer risk; however, this observed possible association needs to be confirmed by future larger analytic studies with more never smoking cases.
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spelling pubmed-33980132012-07-19 Synergistic Effect between Alcohol Consumption and Familial Susceptibility on Lung Cancer Risk among Chinese Men Tse, Lap Ah Yu, Ignatius Tak-sun Wang, Xiao-rong Qiu, Hong Au, Joseph Siu Kie PLoS One Research Article We aimed to examine the effect of alcohol consumption on lung cancer risk stratified by smoking, and to explore whether the impact of alcohol was modified by familial susceptibility to cancer. We recruited 1208 male lung cancer incident cases and 1069 community referents during 2004–2006 and collected their lifetime history of alcohol consumption, cigarette smoking, and family cancer history. Unconditional multivariate logistic regression analysis was performed to estimate the adjusted odds ratio (OR). We tested multiplicative-scale interaction between exposures of interest and examined the additive-scale interaction using synergy index. A moderate association between frequent alcohol consumption and lung cancer was observed among men who had family cancer history (OR = 4.22, 95%CI: 2.46–7.23) after adjustment of smoking and other confounders, while the alcohol effect among men without family history was weak (OR = 1.24, 95%CI: 0.95–1.63) and it became no excess in the never smokers. We observed a consistent synergistic effect between alcohol drinking and family cancer history for all lung cancers and the adenocarcinoma, while there was no multiplicative-scale interaction between the exposures of interest (likelihood ratio test for interaction, p>0.05). Our study revealed a possible synergistic effect between alcohol consumption and familial susceptibility for lung cancer risk; however, this observed possible association needs to be confirmed by future larger analytic studies with more never smoking cases. Public Library of Science 2012-07-16 /pmc/articles/PMC3398013/ /pubmed/22815780 http://dx.doi.org/10.1371/journal.pone.0040647 Text en Tse et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Tse, Lap Ah
Yu, Ignatius Tak-sun
Wang, Xiao-rong
Qiu, Hong
Au, Joseph Siu Kie
Synergistic Effect between Alcohol Consumption and Familial Susceptibility on Lung Cancer Risk among Chinese Men
title Synergistic Effect between Alcohol Consumption and Familial Susceptibility on Lung Cancer Risk among Chinese Men
title_full Synergistic Effect between Alcohol Consumption and Familial Susceptibility on Lung Cancer Risk among Chinese Men
title_fullStr Synergistic Effect between Alcohol Consumption and Familial Susceptibility on Lung Cancer Risk among Chinese Men
title_full_unstemmed Synergistic Effect between Alcohol Consumption and Familial Susceptibility on Lung Cancer Risk among Chinese Men
title_short Synergistic Effect between Alcohol Consumption and Familial Susceptibility on Lung Cancer Risk among Chinese Men
title_sort synergistic effect between alcohol consumption and familial susceptibility on lung cancer risk among chinese men
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398013/
https://www.ncbi.nlm.nih.gov/pubmed/22815780
http://dx.doi.org/10.1371/journal.pone.0040647
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