Cargando…

Physalin F Induces Cell Apoptosis in Human Renal Carcinoma Cells by Targeting NF-kappaB and Generating Reactive Oxygen Species

BACKGROUND: The aim of this study was to determine the molecular mechanisms of physalin F, an effective purified extract of Physalis angulata L. (Solanacae), in renal carcinoma A498 cells. METHODOLOGY/PRINCIPAL FINDINGS: Physalin F was observed to significantly induce cytotoxicity of three human ren...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Szu-Ying, Leu, Yann-Lii, Chang, Ya-Ling, Wu, Tian-Shung, Kuo, Ping-Chung, Liao, Yu-Ren, Teng, Che-Ming, Pan, Shiow-Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398016/ https://www.ncbi.nlm.nih.gov/pubmed/22815798 http://dx.doi.org/10.1371/journal.pone.0040727

Ejemplares similares

NF-kappaB in Lung Tumorigenesis
por: Cai, Zhenjian, et al.
Publicado: (2011)

NF-kappaB and cytokines in pancreatic acinar cells.
por: Kim, H, et al.
Publicado: (2000)

Nuclear factor kappaB (NF-kappaB) pathway as a therapeutic target in rheumatoid arthritis.
por: Jue, D. M., et al.
Publicado: (1999)

Signaling from toxic metals to NF-kappaB and beyond: not just a matter of reactive oxygen species.
por: Chen, Fei, et al.
Publicado: (2002)

NF-kappaB: Two Sides of the Same Coin
por: Pires, Bruno R. B., et al.
Publicado: (2018)

An Update on the Multifaceted Role of NF-kappaB in Endometriosis
por: Liu, Yuanmeng, et al.
Publicado: (2022)

Sensitization of ovarian cancer cells to cisplatin by genistein: the role of NF-kappaB
por: Solomon, Leigh A, et al.
Publicado: (2008)

In silico identification of NF-kappaB-regulated genes in pancreatic beta-cells
por: Naamane, Najib, et al.
Publicado: (2007)

NF-kappaB Is Involved in the Regulation of EMT Genes in Breast Cancer Cells
por: Pires, Bruno R. B., et al.
Publicado: (2017)

Cell-Type Targeted NF-kappaB Inhibition for the Treatment of Inflammatory Diseases
por: Sehnert, Bettina, et al.
Publicado: (2020)

Recent insights into the role of NF-kappaB in ovarian carcinogenesis
por: Alvero, Ayesha B
Publicado: (2010)

NF-kappaB Signaling in Chronic Inflammatory Airway Disease
por: Schuliga, Michael
Publicado: (2015)

Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: involvement of reactive oxygen species.
por: Mendes, A F, et al.
Publicado: (2001)

Prevalence of bortezomib-resistant constitutive NF-kappaB activity in mantle cell lymphoma
por: Yang, David T, et al.
Publicado: (2008)

Role of NF-kappaB2-p100 in regulatory T cell homeostasis and activation
por: Dhar, Atika, et al.
Publicado: (2019)

Interplay of Murine Gammaherpesvirus 68 with NF-kappaB Signaling of the Host
por: Cieniewicz, Brandon, et al.
Publicado: (2016)

NF-kappaB Regulates Redox Status in Breast Cancer Subtypes
por: Pires, Bruno R. B., et al.
Publicado: (2018)

NF-kappaB activation is associated with homocysteine-induced injury in Neuro2a cells
por: Ferlazzo, Nadia, et al.
Publicado: (2008)

Transient degradation of NF-kappaB proteins in macrophages after interaction with mast cell granules.
por: Ito, N, et al.
Publicado: (1998)

Hepatitis C virus fails to activate NF-kappaB signaling in plasmacytoid dendritic cells
por: Stranska, Ruzena, et al.
Publicado: (2012)

NF-KappaB Pathway Is Involved in Bone Marrow Stromal Cell-Produced Pain Relief
por: Guo, Wei, et al.
Publicado: (2018)

Corrigendum: NF-kappaB-inducing kinase regulates stem cell phenotype in breast cancer
por: Vazquez-Santillan, Karla, et al.
Publicado: (2017)

NF-KappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues
por: Meteoglu, Ibrahim, et al.
Publicado: (2008)

Expression of NF-kappaB and cytokines in chronic rejection of transplanted murine heart.
por: Lee, J. R., et al.
Publicado: (2001)

NF-kappaB Mediated Transcriptional Repression of Acid Modifying Hormone Gastrin
por: Datta De, Dipanjana, et al.
Publicado: (2013)

NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review
por: Shih, Ruey-Horng, et al.
Publicado: (2015)

Piperlongumine Improves Lipopolysaccharide-Induced Amyloidogenesis by Suppressing NF-KappaB Pathway
por: Gu, Sun Mi, et al.
Publicado: (2018)

Dihydromyricetin Attenuates Inflammation through TLR4/NF-kappaB Pathway
por: Jing, Nianshui, et al.
Publicado: (2019)

Effects of decoy molecules targeting NF-kappaB transcription factors in Cystic fibrosis IB3–1 cells: Recruitment of NF-kappaB to the IL-8 gene promoter and transcription of the IL-8 gene
por: Finotti, Alessia, et al.
Publicado: (2012)

Regulation of Mcl-1 by constitutive activation of NF-kappaB contributes to cell viability in human esophageal squamous cell carcinoma cells
por: Liu, Haidan, et al.
Publicado: (2014)

Lapatinib–induced NF-kappaB activation sensitizes triple-negative breast cancer cells to proteasome inhibitors
por: Chen, Yun-Ju, et al.
Publicado: (2013)

NF-kappaB mediates the survival of human bronchial epithelial cells exposed to cigarette smoke extract
por: Liu, Xiangde, et al.
Publicado: (2008)

Inhibition of NF-kappaB transcriptional activity enhances fucoxanthinol-induced apoptosis in colorectal cancer cells
por: Tamura, Shuya, et al.
Publicado: (2019)

Suppression of NF-kappaB activation in normal T cells by supernatant fluid from human renal cell carcinomas.
por: Kim, H. J., et al.
Publicado: (1999)

The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB
Publicado: (1996)

Aberrant NF-KappaB Expression in Autism Spectrum Condition: A Mechanism for Neuroinflammation
por: Young, Adam M. H., et al.
Publicado: (2011)

The Receptor Tyrosine Kinase FGFR4 Negatively Regulates NF-kappaB Signaling
por: Drafahl, Kristine A., et al.
Publicado: (2010)

The functional genomic response of developing embryonic submandibular glands to NF-kappaB inhibition
por: Melnick, Michael, et al.
Publicado: (2001)

A functional genomics screen for microRNA regulators of NF-kappaB signaling
por: Olarerin-George, Anthony O, et al.
Publicado: (2013)

Inhibition of astroglial NF-kappaB enhances oligodendrogenesis following spinal cord injury
por: Bracchi-Ricard, Valerie, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_tt63ojp4qjf3kuu4uo7k2mda5c