Cargando…

Myeloid Suppressor Cell Depletion Augments Antitumor Activity in Lung Cancer

BACKGROUND: Myeloid derived suppressor cells (MDSC) are important regulators of immune responses. We evaluated the mechanistic role of MDSC depletion on antigen presenting cell (APC), NK, T cell activities and therapeutic vaccination responses in murine models of lung cancer. PRINCIPAL FINDINGS: Ind...

Descripción completa

Detalles Bibliográficos
Autores principales:	Srivastava, Minu K., Zhu, Li, Harris-White, Marni, Kar, Upendra, Huang, Min, Johnson, Ming F., Lee, Jay M., Elashoff, David, Strieter, Robert, Dubinett, Steven, Sharma, Sherven
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398024/ https://www.ncbi.nlm.nih.gov/pubmed/22815789 http://dx.doi.org/10.1371/journal.pone.0040677

Ejemplares similares

Correction: Myeloid Suppressor Cell Depletion Augments Antitumor Activity in Lung Cancer
por: Srivastava, Minu K., et al.
Publicado: (2012)

Targeting myeloid-derived suppressor cells augments antitumor activity against lung cancer
por: Srivastava, Minu K, et al.
Publicado: (2012)

Targeting MDSCs enhance therapeutic vaccination responses against lung cancer
por: Srivastava, Minu K., et al.
Publicado: (2012)

Novel CCL21-Vault Nanocapsule Intratumoral Delivery Inhibits Lung Cancer Growth
por: Kar, Upendra K., et al.
Publicado: (2011)

Overexpression of CCL-21/Secondary Lymphoid Tissue Chemokine in Human Dendritic Cells Augments Chemotactic Activities for Lymphocytes and Antigen Presenting Cells
por: Riedl, Karen, et al.
Publicado: (2003)

Early intervention with a small molecule inhibitor for tumor nefosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer’s disease
por: Gabbita, S Prasad, et al.
Publicado: (2012)

Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function
por: Serafini, Paolo, et al.
Publicado: (2006)

IL-27 inhibits epithelial-mesenchymal transition and angiogenic factor production in a STAT1-dominant pathway in human non-small cell lung cancer
por: Kachroo, Puja, et al.
Publicado: (2013)

CXCR4 expression on circulating pan-cytokeratin positive cells is associated with survival in patients with advanced non-small cell lung cancer
por: Reckamp, Karen L, et al.
Publicado: (2009)

SLC/CCL21-mediated anti-tumor responses require IFNγ, MIG/CXCL9 and IP-10/CXCL10
por: Sharma, Sherven, et al.
Publicado: (2003)

Vault Nanocapsules as Adjuvants Favor Cell-Mediated over Antibody-Mediated Immune Responses following Immunization of Mice
por: Kar, Upendra K., et al.
Publicado: (2012)

The Role of PPARγ in the Cyclooxygenase Pathway in Lung Cancer
por: Hazra, Saswati, et al.
Publicado: (2008)

Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma
por: Rodriguez, Paulo C., et al.
Publicado: (2005)

Targeting TREM1 augments antitumor T cell immunity by inhibiting myeloid-derived suppressor cells and restraining anti–PD-1 resistance
por: Ajith, Ashwin, et al.
Publicado: (2023)

Depletion of phagocytic myeloid cells triggers spontaneous T cell- and NK cell-dependent antitumor activity
por: Guth, Amanda M., et al.
Publicado: (2012)

Therapeutic targeting with DABIL‐4 depletes myeloid suppressor cells in 4T1 triple‐negative breast cancer model
por: Parveen, Sadiya, et al.
Publicado: (2021)

CCL19 reduces tumour burden in a model of advanced lung cancer
por: Hillinger, S, et al.
Publicado: (2006)

Targeting Myeloid-Derived Suppressor Cells to Enhance the Antitumor Efficacy of Immune Checkpoint Blockade Therapy
por: Li, Xueyan, et al.
Publicado: (2021)

Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia
por: Hayashi, Yasutaka, et al.
Publicado: (2019)

Neutrophils with myeloid derived suppressor function deplete arginine and constrain T cell function in septic shock patients
por: Darcy, Christabelle J, et al.
Publicado: (2014)

Myeloid-derived suppressor cell depletion therapy targets IL-17A-expressing mammary carcinomas
por: Dawod, Bassel, et al.
Publicado: (2020)

Quercetin Potentiates Doxorubicin Mediated Antitumor Effects against Liver Cancer through p53/Bcl-xl
por: Wang, Guanyu, et al.
Publicado: (2012)

Pre-clinical characterization of GMP grade CCL21-gene modified dendritic cells for application in a phase I trial in Non-Small Cell Lung Cancer
por: Baratelli, Felicita, et al.
Publicado: (2008)

CD205(+) polymorphonuclear myeloid‐derived suppressor cells suppress antitumor immunity by overexpressing GLUT3
por: Fu, Chenghao, et al.
Publicado: (2021)

NAMPT-targeting PROTAC promotes antitumor immunity via suppressing myeloid-derived suppressor cell expansion
por: Wu, Ying, et al.
Publicado: (2022)

Technical Feasibility and Safety of Repeated Computed Tomography–Guided Transthoracic Intratumoral Injection of Gene-Modified Cellular Immunotherapy in Metastatic NSCLC
por: Shahrouki, Puja, et al.
Publicado: (2021)

An Agent-based Model for Investigating the Effect of Myeloid-Derived Suppressor Cells and its Depletion on Tumor Immune Surveillance
por: Allahverdy, Armin, et al.
Publicado: (2019)

CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
por: Rodriguez-Garcia, Alba, et al.
Publicado: (2021)

Targeting depletion of myeloid-derived suppressor cells potentiates PD-L1 blockade efficacy in gastric and colon cancers
por: Tang, Yao, et al.
Publicado: (2022)

PD-L1 expression correlates with immune response in a Phase I trial of CCL21 gene modified dendritic cell therapy in lung cancer
por: Lee, Jay M, et al.
Publicado: (2014)

Selective depletion of polymorphonuclear myeloid derived suppressor cells in tumor beds with near infrared photoimmunotherapy enhances host immune response
por: Kato, Takuya, et al.
Publicado: (2022)

Depletion of microglia augments the dopaminergic neurotoxicity of MPTP
por: Yang, Xiaoxia, et al.
Publicado: (2018)

Myeloid Derived Suppressor Cells in Chronic Myeloid Leukemia
por: Giallongo, Cesarina, et al.
Publicado: (2015)

Treatment of Tumors with Vitamin E Suppresses Myeloid Derived Suppressor Cells and Enhances CD8+ T Cell-Mediated Antitumor Effects
por: Kang, Tae Heung, et al.
Publicado: (2014)

Myeloid-Derived Suppressor Cells Specifically Suppress IFN-γ Production and Antitumor Cytotoxic Activity of Vδ2 T Cells
por: Sacchi, Alessandra, et al.
Publicado: (2018)

3,3′-Diindolylmethane improves antitumor immune responses of PD-1 blockade via inhibiting myeloid-derived suppressor cells
por: Sun, Qi, et al.
Publicado: (2022)

6-Thioguanine-loaded polymeric micelles deplete myeloid-derived suppressor cells and enhance the efficacy of T cell immunotherapy in tumor-bearing mice
por: Jeanbart, Laura, et al.
Publicado: (2015)

Sunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication
por: Draghiciu, Oana, et al.
Publicado: (2015)

Myeloid-Derived Suppressor Cells in Sepsis
por: Lai, Dengming, et al.
Publicado: (2014)

Myeloid-Derived Suppressor Cells in Sepsis
por: Schrijver, Irene T., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_rcq28ug4md5epo1qcpspr8fvr7