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Clues for Diagnosing Primary Pancreatic Lymphoma

Primary pancreatic lymphoma (PPL), a localized lymphoma in the pancreas, accounts for <0.5% of all pancreatic masses and presents with symptoms favoring the more common adenocarcinoma. It is important to differentiate PPL from adenocarcinoma since treatment and prognosis differ considerably. PPL...

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Autores principales: Li, Zhongzhen, Zhang, Shaoxiong, Vasdani, Nadiya, Castillo, Eddy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398069/
https://www.ncbi.nlm.nih.gov/pubmed/22855659
http://dx.doi.org/10.1159/000339968
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author Li, Zhongzhen
Zhang, Shaoxiong
Vasdani, Nadiya
Castillo, Eddy
author_facet Li, Zhongzhen
Zhang, Shaoxiong
Vasdani, Nadiya
Castillo, Eddy
author_sort Li, Zhongzhen
collection PubMed
description Primary pancreatic lymphoma (PPL), a localized lymphoma in the pancreas, accounts for <0.5% of all pancreatic masses and presents with symptoms favoring the more common adenocarcinoma. It is important to differentiate PPL from adenocarcinoma since treatment and prognosis differ considerably. PPL is potentially curable with chemotherapy, especially if it is diagnosed at early stages. A definitive diagnosis can only be based on histopathological findings. Endoscopic ultrasound-guided fine needle aspiration (EUS-guided FNA) is a reliable, minimally invasive and cost-effective method for this purpose. Even though there are neither typical clinical features nor specific biomarker for the diagnosis of PPL, certain common presentations have been observed which may indicate PPL. We herein present the case of a 43-year-old man who was successfully diagnosed with PPL by EUS-guided FNA. His clinical, laboratory and radiographic findings supported PPL over adenocarcinoma as well. This case demonstrates that high clinical suspicion based on clinical, laboratory and imaging features is critical in PPL diagnosis and management.
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spelling pubmed-33980692012-08-01 Clues for Diagnosing Primary Pancreatic Lymphoma Li, Zhongzhen Zhang, Shaoxiong Vasdani, Nadiya Castillo, Eddy Case Rep Gastroenterol Published online: July, 2012 Primary pancreatic lymphoma (PPL), a localized lymphoma in the pancreas, accounts for <0.5% of all pancreatic masses and presents with symptoms favoring the more common adenocarcinoma. It is important to differentiate PPL from adenocarcinoma since treatment and prognosis differ considerably. PPL is potentially curable with chemotherapy, especially if it is diagnosed at early stages. A definitive diagnosis can only be based on histopathological findings. Endoscopic ultrasound-guided fine needle aspiration (EUS-guided FNA) is a reliable, minimally invasive and cost-effective method for this purpose. Even though there are neither typical clinical features nor specific biomarker for the diagnosis of PPL, certain common presentations have been observed which may indicate PPL. We herein present the case of a 43-year-old man who was successfully diagnosed with PPL by EUS-guided FNA. His clinical, laboratory and radiographic findings supported PPL over adenocarcinoma as well. This case demonstrates that high clinical suspicion based on clinical, laboratory and imaging features is critical in PPL diagnosis and management. S. Karger AG 2012-07-05 /pmc/articles/PMC3398069/ /pubmed/22855659 http://dx.doi.org/10.1159/000339968 Text en Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: July, 2012
Li, Zhongzhen
Zhang, Shaoxiong
Vasdani, Nadiya
Castillo, Eddy
Clues for Diagnosing Primary Pancreatic Lymphoma
title Clues for Diagnosing Primary Pancreatic Lymphoma
title_full Clues for Diagnosing Primary Pancreatic Lymphoma
title_fullStr Clues for Diagnosing Primary Pancreatic Lymphoma
title_full_unstemmed Clues for Diagnosing Primary Pancreatic Lymphoma
title_short Clues for Diagnosing Primary Pancreatic Lymphoma
title_sort clues for diagnosing primary pancreatic lymphoma
topic Published online: July, 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398069/
https://www.ncbi.nlm.nih.gov/pubmed/22855659
http://dx.doi.org/10.1159/000339968
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