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Disseminated Intracranial Ewing's Sarcoma in an Adult: A Rare and Difficult Diagnosis

The Ewing sarcoma family of tumors comprises a rare class of cancers of mesenchymal origin. Cases of Ewing's sarcoma in the central nervous system – specifically, intracranial Ewing's – are extremely rare. Almost all reported cases have occurred in children. However, this rare presentation...

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Autores principales: Lou, Emil, Sumrall, Ashley L., Cummings, Thomas J., Korones, David N., Weaver, Susan A., Peters, Katherine B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398078/
https://www.ncbi.nlm.nih.gov/pubmed/22933997
http://dx.doi.org/10.1159/000339721
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author Lou, Emil
Sumrall, Ashley L.
Cummings, Thomas J.
Korones, David N.
Weaver, Susan A.
Peters, Katherine B.
author_facet Lou, Emil
Sumrall, Ashley L.
Cummings, Thomas J.
Korones, David N.
Weaver, Susan A.
Peters, Katherine B.
author_sort Lou, Emil
collection PubMed
description The Ewing sarcoma family of tumors comprises a rare class of cancers of mesenchymal origin. Cases of Ewing's sarcoma in the central nervous system – specifically, intracranial Ewing's – are extremely rare. Almost all reported cases have occurred in children. However, this rare presentation can also occur in the adult population. It is important to distinguish these tumors from primitive neuroectodermal tumors at the time of diagnosis. Testing for EWSR1(22q12) gene rearrangement using fluorescence in situ hybridization is a useful tool for making the distinction between these 2 similar but distinct entities. We present here the case of a middle-aged male patient with intracranial Ewing's sarcoma, and discuss diagnostic challenges and potential new treatment approaches for this rare disease.
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spelling pubmed-33980782012-08-29 Disseminated Intracranial Ewing's Sarcoma in an Adult: A Rare and Difficult Diagnosis Lou, Emil Sumrall, Ashley L. Cummings, Thomas J. Korones, David N. Weaver, Susan A. Peters, Katherine B. Case Rep Oncol Published online: June, 2012 The Ewing sarcoma family of tumors comprises a rare class of cancers of mesenchymal origin. Cases of Ewing's sarcoma in the central nervous system – specifically, intracranial Ewing's – are extremely rare. Almost all reported cases have occurred in children. However, this rare presentation can also occur in the adult population. It is important to distinguish these tumors from primitive neuroectodermal tumors at the time of diagnosis. Testing for EWSR1(22q12) gene rearrangement using fluorescence in situ hybridization is a useful tool for making the distinction between these 2 similar but distinct entities. We present here the case of a middle-aged male patient with intracranial Ewing's sarcoma, and discuss diagnostic challenges and potential new treatment approaches for this rare disease. S. Karger AG 2012-06-21 /pmc/articles/PMC3398078/ /pubmed/22933997 http://dx.doi.org/10.1159/000339721 Text en Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: June, 2012
Lou, Emil
Sumrall, Ashley L.
Cummings, Thomas J.
Korones, David N.
Weaver, Susan A.
Peters, Katherine B.
Disseminated Intracranial Ewing's Sarcoma in an Adult: A Rare and Difficult Diagnosis
title Disseminated Intracranial Ewing's Sarcoma in an Adult: A Rare and Difficult Diagnosis
title_full Disseminated Intracranial Ewing's Sarcoma in an Adult: A Rare and Difficult Diagnosis
title_fullStr Disseminated Intracranial Ewing's Sarcoma in an Adult: A Rare and Difficult Diagnosis
title_full_unstemmed Disseminated Intracranial Ewing's Sarcoma in an Adult: A Rare and Difficult Diagnosis
title_short Disseminated Intracranial Ewing's Sarcoma in an Adult: A Rare and Difficult Diagnosis
title_sort disseminated intracranial ewing's sarcoma in an adult: a rare and difficult diagnosis
topic Published online: June, 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398078/
https://www.ncbi.nlm.nih.gov/pubmed/22933997
http://dx.doi.org/10.1159/000339721
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