Myeloid-derived suppressor cells: mechanisms of action and recent advances in their role in transplant tolerance

Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature hematopoietic precursors known to suppress immune responses in infection, chronic inflammation, cancer, and autoimmunity. In this paper, we review recent findings detailing their mode of action and discuss recent repo...

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Autores principales: Dilek, Nahzli, Vuillefroy de Silly, Romain, Blancho, Gilles, Vanhove, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398399/
https://www.ncbi.nlm.nih.gov/pubmed/22822406
http://dx.doi.org/10.3389/fimmu.2012.00208
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author Dilek, Nahzli
Vuillefroy de Silly, Romain
Blancho, Gilles
Vanhove, Bernard
author_facet Dilek, Nahzli
Vuillefroy de Silly, Romain
Blancho, Gilles
Vanhove, Bernard
author_sort Dilek, Nahzli
collection PubMed
description Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature hematopoietic precursors known to suppress immune responses in infection, chronic inflammation, cancer, and autoimmunity. In this paper, we review recent findings detailing their mode of action and discuss recent reports that suggest that MDSC are also expanded during transplantation and that modulation of MDSC can participate in preventing graft rejection as well as graft-versus-host disease.
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spelling pubmed-33983992012-07-20 Myeloid-derived suppressor cells: mechanisms of action and recent advances in their role in transplant tolerance Dilek, Nahzli Vuillefroy de Silly, Romain Blancho, Gilles Vanhove, Bernard Front Immunol Immunology Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature hematopoietic precursors known to suppress immune responses in infection, chronic inflammation, cancer, and autoimmunity. In this paper, we review recent findings detailing their mode of action and discuss recent reports that suggest that MDSC are also expanded during transplantation and that modulation of MDSC can participate in preventing graft rejection as well as graft-versus-host disease. Frontiers Research Foundation 2012-07-17 /pmc/articles/PMC3398399/ /pubmed/22822406 http://dx.doi.org/10.3389/fimmu.2012.00208 Text en Copyright © Dilek, Vuillefroy de Silly, Blancho and Vanhove http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) , which permits use, distribution, and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any thirdparty graphics etc.
spellingShingle Immunology
Dilek, Nahzli
Vuillefroy de Silly, Romain
Blancho, Gilles
Vanhove, Bernard
Myeloid-derived suppressor cells: mechanisms of action and recent advances in their role in transplant tolerance
title Myeloid-derived suppressor cells: mechanisms of action and recent advances in their role in transplant tolerance
title_full Myeloid-derived suppressor cells: mechanisms of action and recent advances in their role in transplant tolerance
title_fullStr Myeloid-derived suppressor cells: mechanisms of action and recent advances in their role in transplant tolerance
title_full_unstemmed Myeloid-derived suppressor cells: mechanisms of action and recent advances in their role in transplant tolerance
title_short Myeloid-derived suppressor cells: mechanisms of action and recent advances in their role in transplant tolerance
title_sort myeloid-derived suppressor cells: mechanisms of action and recent advances in their role in transplant tolerance
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398399/
https://www.ncbi.nlm.nih.gov/pubmed/22822406
http://dx.doi.org/10.3389/fimmu.2012.00208
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AT blanchogilles myeloidderivedsuppressorcellsmechanismsofactionandrecentadvancesintheirroleintransplanttolerance
AT vanhovebernard myeloidderivedsuppressorcellsmechanismsofactionandrecentadvancesintheirroleintransplanttolerance

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