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Syphilis Infection during Pregnancy: Fetal Risks and Clinical Management

Congenital syphilis is still a cause of perinatal morbidity and mortality. Untreated maternal infection leads to adverse pregnancy outcomes, including early fetal loss, stillbirth, prematurity, low birth weight, neonatal and infant death, and congenital disease among newborns. Clinical manifestation...

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Autores principales: De Santis, Marco, De Luca, Carmen, Mappa, Ilenia, Spagnuolo, Terryann, Licameli, Angelo, Straface, Gianluca, Scambia, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398589/
https://www.ncbi.nlm.nih.gov/pubmed/22829747
http://dx.doi.org/10.1155/2012/430585
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author De Santis, Marco
De Luca, Carmen
Mappa, Ilenia
Spagnuolo, Terryann
Licameli, Angelo
Straface, Gianluca
Scambia, Giovanni
author_facet De Santis, Marco
De Luca, Carmen
Mappa, Ilenia
Spagnuolo, Terryann
Licameli, Angelo
Straface, Gianluca
Scambia, Giovanni
author_sort De Santis, Marco
collection PubMed
description Congenital syphilis is still a cause of perinatal morbidity and mortality. Untreated maternal infection leads to adverse pregnancy outcomes, including early fetal loss, stillbirth, prematurity, low birth weight, neonatal and infant death, and congenital disease among newborns. Clinical manifestations of congenital syphilis are influenced by gestational age, stage of maternal syphilis, maternal treatment, and immunological response of the fetus. It has been traditionally classified in early congenital syphilis and late congenital syphilis. Diagnosis of maternal infection is based on clinical findings, serological tests, and direct identification of treponemes in clinical specimens. Adequate treatment of maternal infection is effective for preventing maternal transmission to the fetus and for treating fetal infection. Prenatal diagnosis of congenital syphilis includes noninvasive and invasive diagnosis. Serological screening during pregnancy and during preconception period should be performed to reduce the incidence of congenital syphilis.
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spelling pubmed-33985892012-07-24 Syphilis Infection during Pregnancy: Fetal Risks and Clinical Management De Santis, Marco De Luca, Carmen Mappa, Ilenia Spagnuolo, Terryann Licameli, Angelo Straface, Gianluca Scambia, Giovanni Infect Dis Obstet Gynecol Review Article Congenital syphilis is still a cause of perinatal morbidity and mortality. Untreated maternal infection leads to adverse pregnancy outcomes, including early fetal loss, stillbirth, prematurity, low birth weight, neonatal and infant death, and congenital disease among newborns. Clinical manifestations of congenital syphilis are influenced by gestational age, stage of maternal syphilis, maternal treatment, and immunological response of the fetus. It has been traditionally classified in early congenital syphilis and late congenital syphilis. Diagnosis of maternal infection is based on clinical findings, serological tests, and direct identification of treponemes in clinical specimens. Adequate treatment of maternal infection is effective for preventing maternal transmission to the fetus and for treating fetal infection. Prenatal diagnosis of congenital syphilis includes noninvasive and invasive diagnosis. Serological screening during pregnancy and during preconception period should be performed to reduce the incidence of congenital syphilis. Hindawi Publishing Corporation 2012 2012-07-04 /pmc/articles/PMC3398589/ /pubmed/22829747 http://dx.doi.org/10.1155/2012/430585 Text en Copyright © 2012 Marco De Santis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
De Santis, Marco
De Luca, Carmen
Mappa, Ilenia
Spagnuolo, Terryann
Licameli, Angelo
Straface, Gianluca
Scambia, Giovanni
Syphilis Infection during Pregnancy: Fetal Risks and Clinical Management
title Syphilis Infection during Pregnancy: Fetal Risks and Clinical Management
title_full Syphilis Infection during Pregnancy: Fetal Risks and Clinical Management
title_fullStr Syphilis Infection during Pregnancy: Fetal Risks and Clinical Management
title_full_unstemmed Syphilis Infection during Pregnancy: Fetal Risks and Clinical Management
title_short Syphilis Infection during Pregnancy: Fetal Risks and Clinical Management
title_sort syphilis infection during pregnancy: fetal risks and clinical management
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398589/
https://www.ncbi.nlm.nih.gov/pubmed/22829747
http://dx.doi.org/10.1155/2012/430585
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