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Redox Regulation of Cysteine-Dependent Enzymes in Neurodegeneration
Evidence of increased oxidative stress has been found in various neurodegenerative diseases and conditions. While it is unclear whether oxidative stress is a cause or effect, protein, lipid, and DNA have all been found to be susceptible to oxidant-induced modifications that alter their function. Res...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398591/ https://www.ncbi.nlm.nih.gov/pubmed/22829832 http://dx.doi.org/10.1155/2012/703164 |
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author | Guttmann, Rodney P. Powell, Tamara J. |
author_facet | Guttmann, Rodney P. Powell, Tamara J. |
author_sort | Guttmann, Rodney P. |
collection | PubMed |
description | Evidence of increased oxidative stress has been found in various neurodegenerative diseases and conditions. While it is unclear whether oxidative stress is a cause or effect, protein, lipid, and DNA have all been found to be susceptible to oxidant-induced modifications that alter their function. Results of clinical trials based on the oxidative-stress theory have been mixed, though data continues to indicate that prevention of high levels of oxidative stress is beneficial for health and increases longevity. Due to the highly reactive nature of the sulfhydryl group, the focus of this paper is on the impact of oxidative stress on cysteine-dependent enzymes and how oxidative stress may contribute to neurological dysfunction through this selected group of proteins. |
format | Online Article Text |
id | pubmed-3398591 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33985912012-07-24 Redox Regulation of Cysteine-Dependent Enzymes in Neurodegeneration Guttmann, Rodney P. Powell, Tamara J. Int J Cell Biol Review Article Evidence of increased oxidative stress has been found in various neurodegenerative diseases and conditions. While it is unclear whether oxidative stress is a cause or effect, protein, lipid, and DNA have all been found to be susceptible to oxidant-induced modifications that alter their function. Results of clinical trials based on the oxidative-stress theory have been mixed, though data continues to indicate that prevention of high levels of oxidative stress is beneficial for health and increases longevity. Due to the highly reactive nature of the sulfhydryl group, the focus of this paper is on the impact of oxidative stress on cysteine-dependent enzymes and how oxidative stress may contribute to neurological dysfunction through this selected group of proteins. Hindawi Publishing Corporation 2012 2012-07-05 /pmc/articles/PMC3398591/ /pubmed/22829832 http://dx.doi.org/10.1155/2012/703164 Text en Copyright © 2012 R. P. Guttmann and T. J. Powell. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Guttmann, Rodney P. Powell, Tamara J. Redox Regulation of Cysteine-Dependent Enzymes in Neurodegeneration |
title | Redox Regulation of Cysteine-Dependent Enzymes in Neurodegeneration |
title_full | Redox Regulation of Cysteine-Dependent Enzymes in Neurodegeneration |
title_fullStr | Redox Regulation of Cysteine-Dependent Enzymes in Neurodegeneration |
title_full_unstemmed | Redox Regulation of Cysteine-Dependent Enzymes in Neurodegeneration |
title_short | Redox Regulation of Cysteine-Dependent Enzymes in Neurodegeneration |
title_sort | redox regulation of cysteine-dependent enzymes in neurodegeneration |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398591/ https://www.ncbi.nlm.nih.gov/pubmed/22829832 http://dx.doi.org/10.1155/2012/703164 |
work_keys_str_mv | AT guttmannrodneyp redoxregulationofcysteinedependentenzymesinneurodegeneration AT powelltamaraj redoxregulationofcysteinedependentenzymesinneurodegeneration |