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Model-based global sensitivity analysis as applied to identification of anti-cancer drug targets and biomarkers of drug resistance in the ErbB2/3 network
High levels of variability in cancer-related cellular signalling networks and a lack of parameter identifiability in large-scale network models hamper translation of the results of modelling studies into the process of anti-cancer drug development. Recently global sensitivity analysis (GSA) has been...
Autores principales: | Lebedeva, Galina, Sorokin, Anatoly, Faratian, Dana, Mullen, Peter, Goltsov, Alexey, Langdon, Simon P., Harrison, David J., Goryanin, Igor |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science B.V
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398788/ https://www.ncbi.nlm.nih.gov/pubmed/22085636 http://dx.doi.org/10.1016/j.ejps.2011.10.026 |
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