Cerebrovascular Function in Aging and Dementia: A Systematic Review of Transcranial Doppler Studies

BACKGROUND/AIM: The contribution of cerebrovascular dysfunction to the manifestation of dementia and cognitive decline in late life is gaining increased attention. We aimed to systematically review evidence for associations between dementia or aging and cerebrovascular function as measured using tra...

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Autores principales: Keage, Hannah A.D., Churches, Owen F., Kohler, Mark, Pomeroy, Danielle, Luppino, Rocco, Bartolo, Michelle L., Elliott, Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2012
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398823/
https://www.ncbi.nlm.nih.gov/pubmed/22822408
http://dx.doi.org/10.1159/000339234
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author Keage, Hannah A.D.
Churches, Owen F.
Kohler, Mark
Pomeroy, Danielle
Luppino, Rocco
Bartolo, Michelle L.
Elliott, Scott
author_facet Keage, Hannah A.D.
Churches, Owen F.
Kohler, Mark
Pomeroy, Danielle
Luppino, Rocco
Bartolo, Michelle L.
Elliott, Scott
author_sort Keage, Hannah A.D.
collection PubMed
description BACKGROUND/AIM: The contribution of cerebrovascular dysfunction to the manifestation of dementia and cognitive decline in late life is gaining increased attention. We aimed to systematically review evidence for associations between dementia or aging and cerebrovascular function as measured using transcranial Doppler (TCD) examination. METHODS: A total of 1,172 articles were retrieved from PsychInfo and PubMed searches, and 34 relevant articles were identified using a variety of TCD methods. RESULTS: The pulsatility index (vessel resistance), spontaneous emboli and cerebrovascular reactivity to hyper-/hypocapnia appeared good discriminators of dementia. Aging was associated with a slowing in blood flow velocity. CONCLUSION: TCD ultrasonography is inexpensive, portable and well tolerated by aged and demented subjects. The technique stands to make a valuable contribution to the knowledge regarding the underlying functional biology of age-related cognitive change and dementia.
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spelling pubmed-33988232012-07-20 Cerebrovascular Function in Aging and Dementia: A Systematic Review of Transcranial Doppler Studies Keage, Hannah A.D. Churches, Owen F. Kohler, Mark Pomeroy, Danielle Luppino, Rocco Bartolo, Michelle L. Elliott, Scott Dement Geriatr Cogn Dis Extra Original Research Article BACKGROUND/AIM: The contribution of cerebrovascular dysfunction to the manifestation of dementia and cognitive decline in late life is gaining increased attention. We aimed to systematically review evidence for associations between dementia or aging and cerebrovascular function as measured using transcranial Doppler (TCD) examination. METHODS: A total of 1,172 articles were retrieved from PsychInfo and PubMed searches, and 34 relevant articles were identified using a variety of TCD methods. RESULTS: The pulsatility index (vessel resistance), spontaneous emboli and cerebrovascular reactivity to hyper-/hypocapnia appeared good discriminators of dementia. Aging was associated with a slowing in blood flow velocity. CONCLUSION: TCD ultrasonography is inexpensive, portable and well tolerated by aged and demented subjects. The technique stands to make a valuable contribution to the knowledge regarding the underlying functional biology of age-related cognitive change and dementia. S. Karger AG 2012-06-29 /pmc/articles/PMC3398823/ /pubmed/22822408 http://dx.doi.org/10.1159/000339234 Text en Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Original Research Article
Keage, Hannah A.D.
Churches, Owen F.
Kohler, Mark
Pomeroy, Danielle
Luppino, Rocco
Bartolo, Michelle L.
Elliott, Scott
Cerebrovascular Function in Aging and Dementia: A Systematic Review of Transcranial Doppler Studies
title Cerebrovascular Function in Aging and Dementia: A Systematic Review of Transcranial Doppler Studies
title_full Cerebrovascular Function in Aging and Dementia: A Systematic Review of Transcranial Doppler Studies
title_fullStr Cerebrovascular Function in Aging and Dementia: A Systematic Review of Transcranial Doppler Studies
title_full_unstemmed Cerebrovascular Function in Aging and Dementia: A Systematic Review of Transcranial Doppler Studies
title_short Cerebrovascular Function in Aging and Dementia: A Systematic Review of Transcranial Doppler Studies
title_sort cerebrovascular function in aging and dementia: a systematic review of transcranial doppler studies
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398823/
https://www.ncbi.nlm.nih.gov/pubmed/22822408
http://dx.doi.org/10.1159/000339234
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