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Hemodynamic effects of peri-operative statin therapy in on-pump cardiac surgery patients

BACKGROUND: Peri-operative statin therapy in cardiac surgery cases is reported to reduce the rate of mortality, stroke, postoperative atrial fibrillation, and systemic inflammation. Systemic inflammation could affect the hemodynamic parameters and stability. We set out to study the effect of statin...

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Autores principales: Hinz, Jose, Gehoff, Philipp, Schotola, Hanna, Hosseini, Morteza Tavakkoli, Didilis, Vassilios N, Jebran, Ahmad Fawad, Gehoff, Anastasia, Wiese, Christoph H, Schulz, Egbert Godehard, Schoendube, Friedrich Albert, Popov, Aron Frederik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398842/
https://www.ncbi.nlm.nih.gov/pubmed/22533985
http://dx.doi.org/10.1186/1749-8090-7-39
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author Hinz, Jose
Gehoff, Philipp
Schotola, Hanna
Hosseini, Morteza Tavakkoli
Didilis, Vassilios N
Jebran, Ahmad Fawad
Gehoff, Anastasia
Wiese, Christoph H
Schulz, Egbert Godehard
Schoendube, Friedrich Albert
Popov, Aron Frederik
author_facet Hinz, Jose
Gehoff, Philipp
Schotola, Hanna
Hosseini, Morteza Tavakkoli
Didilis, Vassilios N
Jebran, Ahmad Fawad
Gehoff, Anastasia
Wiese, Christoph H
Schulz, Egbert Godehard
Schoendube, Friedrich Albert
Popov, Aron Frederik
author_sort Hinz, Jose
collection PubMed
description BACKGROUND: Peri-operative statin therapy in cardiac surgery cases is reported to reduce the rate of mortality, stroke, postoperative atrial fibrillation, and systemic inflammation. Systemic inflammation could affect the hemodynamic parameters and stability. We set out to study the effect of statin therapy on perioperative hemodynamic parameters and its clinical outcome. METHODS: In a single center study from 2006 to 2007, peri-operative hemodynamic parameters of 478 patients, who underwent cardiac surgery with cardiopulmonary bypass, were measured. Patients were divided into those who received perioperative statin therapy (n = 276; statin group) and those who did not receive statin therapy (n = 202; no-statin group). The two groups were compared together using Kolmogorov-Smirnov-Test, Fisher’s-Exact-Test, and Student’s-T-test. A p value < 0.05 was considered as significant. RESULTS: There was no significant difference in the preoperative risk factors. Onset of postoperative atrial fibrillation was not affected by statin therapy. Extended hemodynamic measurements revealed no significant difference between the two groups, apart from Systemic Vascular Resistance Index (SVRI) . The no-statin group had a significantly higher SVRI (882 ± 206 vs. 1050 ± 501 dyn s/cm(5)/m(2), p = 0.022). Inotropic support was the same in both groups and no significant difference in the mortality rate was noticed. Also, hemodynamic parameters were not affected by different types and doses of statins. CONCLUSIONS: Perioperative statin therapy for patients undergoing on-pump coronary bypass grafting or valvular surgery, does not affect the hemodynamic parameters and its clinical outcome.
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spelling pubmed-33988422012-07-18 Hemodynamic effects of peri-operative statin therapy in on-pump cardiac surgery patients Hinz, Jose Gehoff, Philipp Schotola, Hanna Hosseini, Morteza Tavakkoli Didilis, Vassilios N Jebran, Ahmad Fawad Gehoff, Anastasia Wiese, Christoph H Schulz, Egbert Godehard Schoendube, Friedrich Albert Popov, Aron Frederik J Cardiothorac Surg Research Article BACKGROUND: Peri-operative statin therapy in cardiac surgery cases is reported to reduce the rate of mortality, stroke, postoperative atrial fibrillation, and systemic inflammation. Systemic inflammation could affect the hemodynamic parameters and stability. We set out to study the effect of statin therapy on perioperative hemodynamic parameters and its clinical outcome. METHODS: In a single center study from 2006 to 2007, peri-operative hemodynamic parameters of 478 patients, who underwent cardiac surgery with cardiopulmonary bypass, were measured. Patients were divided into those who received perioperative statin therapy (n = 276; statin group) and those who did not receive statin therapy (n = 202; no-statin group). The two groups were compared together using Kolmogorov-Smirnov-Test, Fisher’s-Exact-Test, and Student’s-T-test. A p value < 0.05 was considered as significant. RESULTS: There was no significant difference in the preoperative risk factors. Onset of postoperative atrial fibrillation was not affected by statin therapy. Extended hemodynamic measurements revealed no significant difference between the two groups, apart from Systemic Vascular Resistance Index (SVRI) . The no-statin group had a significantly higher SVRI (882 ± 206 vs. 1050 ± 501 dyn s/cm(5)/m(2), p = 0.022). Inotropic support was the same in both groups and no significant difference in the mortality rate was noticed. Also, hemodynamic parameters were not affected by different types and doses of statins. CONCLUSIONS: Perioperative statin therapy for patients undergoing on-pump coronary bypass grafting or valvular surgery, does not affect the hemodynamic parameters and its clinical outcome. BioMed Central 2012-07-13 /pmc/articles/PMC3398842/ /pubmed/22533985 http://dx.doi.org/10.1186/1749-8090-7-39 Text en Copyright ©2012 Hinz et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hinz, Jose
Gehoff, Philipp
Schotola, Hanna
Hosseini, Morteza Tavakkoli
Didilis, Vassilios N
Jebran, Ahmad Fawad
Gehoff, Anastasia
Wiese, Christoph H
Schulz, Egbert Godehard
Schoendube, Friedrich Albert
Popov, Aron Frederik
Hemodynamic effects of peri-operative statin therapy in on-pump cardiac surgery patients
title Hemodynamic effects of peri-operative statin therapy in on-pump cardiac surgery patients
title_full Hemodynamic effects of peri-operative statin therapy in on-pump cardiac surgery patients
title_fullStr Hemodynamic effects of peri-operative statin therapy in on-pump cardiac surgery patients
title_full_unstemmed Hemodynamic effects of peri-operative statin therapy in on-pump cardiac surgery patients
title_short Hemodynamic effects of peri-operative statin therapy in on-pump cardiac surgery patients
title_sort hemodynamic effects of peri-operative statin therapy in on-pump cardiac surgery patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398842/
https://www.ncbi.nlm.nih.gov/pubmed/22533985
http://dx.doi.org/10.1186/1749-8090-7-39
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