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Osteoblast-secreted collagen upregulates paracrine Sonic hedgehog signaling by prostate cancer cells and enhances osteoblast differentiation

BACKGROUND: Induction of osteoblast differentiation by paracrine Sonic hedgehog (Shh) signaling may be a mechanism through which Shh-expressing prostate cancer cells initiate changes in the bone microenvironment and promote metastases. A hallmark of osteoblast differentiation is the formation of mat...

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Detalles Bibliográficos
Autores principales:	Zunich, Samantha M, Valdovinos, Maria, Douglas, Taneka, Walterhouse, David, Iannaccone, Philip, Lamm, Marilyn LG
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398858/ https://www.ncbi.nlm.nih.gov/pubmed/22559324 http://dx.doi.org/10.1186/1476-4598-11-30

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