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Assessment of Strain-Specific PrP(Sc) Elongation Rates Revealed a Transformation of PrP(Sc) Properties during Protein Misfolding Cyclic Amplification
Prion replication is believed to consist of two components, a growth or elongation of infectious isoform of the prion protein (PrP(Sc)) particles and their fragmentation, a process that provides new replication centers. The current study introduced an experimental approach that employs Protein Misfo...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398882/ https://www.ncbi.nlm.nih.gov/pubmed/22815972 http://dx.doi.org/10.1371/journal.pone.0041210 |