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The Inositol Phosphatase SHIP-1 Inhibits NOD2-Induced NF-κB Activation by Disturbing the Interaction of XIAP with RIP2
SHIP-1 is an inositol phosphatase predominantly expressed in hematopoietic cells. Over the ten past years, SHIP-1 has been described as an important regulator of immune functions. Here, we characterize a new inhibitory function for SHIP-1 in NOD2 signaling. NOD2 is a crucial cytoplasmic bacterial se...
Autores principales: | Condé, Claude, Rambout, Xavier, Lebrun, Marielle, Lecat, Aurore, Di Valentin, Emmanuel, Dequiedt, Franck, Piette, Jacques, Gloire, Geoffrey, Legrand, Sylvie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398883/ https://www.ncbi.nlm.nih.gov/pubmed/22815893 http://dx.doi.org/10.1371/journal.pone.0041005 |
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